Aberrant lymphocyte trafficking in murine systemic lupus erythematosus

The patterns of migration of lymphoid cells from autoimmune-prone MRL-lpr/lpr, C57BL/6-lpr/lpr, MRL-+/+, and NZB mice were compared to those from sex and age-matched, normal CBA, C57BL/6, and BALB/C mice. Chromium-51-labelled spleen and lymph node cells from all autoimmune mice tested homed preferen...

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Veröffentlicht in:	Rheumatology international 1986-01, Vol.6 (5), p.215-219
Hauptverfasser:	Schrieber, L, Steinberg, A D, Rosenberg, Y J, Csehi, E E, Paull, S A, Santoro, T J
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals Autoimmune Diseases - immunology Cell Movement Disease Models, Animal Lupus Erythematosus, Systemic - immunology Lymph Nodes - immunology Lymph Nodes - pathology Lymphocytes - immunology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred CBA Spleen - immunology Spleen - pathology
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Zusammenfassung:	The patterns of migration of lymphoid cells from autoimmune-prone MRL-lpr/lpr, C57BL/6-lpr/lpr, MRL-+/+, and NZB mice were compared to those from sex and age-matched, normal CBA, C57BL/6, and BALB/C mice. Chromium-51-labelled spleen and lymph node cells from all autoimmune mice tested homed preferentially to the spleen relative to lymph node of the recipient strain. The data indicate that defects in lymphocyte trafficking are widespread in murine lupus and suggest a role for abnormal lymphocyte migration in the pathogenesis of this disease.
ISSN:	0172-8172 1437-160X
DOI:	10.1007/BF00541370