Nociception and opioid-induced analgesia in lean (Fa/−) and obese (fa/fa) Zucker rats
Previous research indicates a possible interrelationship between the endogenous opioids (EO), nociception and food-intake. We therefore considered the hyperphagic obese Zucker rat a good candidate for abnormal responses to nociceptive stimuli. Pairs of lean and obese sisters were tested for latency...
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| Veröffentlicht in: | Physiology & behavior 1986, Vol.38 (2), p.215-218 |
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| container_title | Physiology & behavior |
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| creator | Roane, David S. Porter, Johnny R. |
| description | Previous research indicates a possible interrelationship between the endogenous opioids (EO), nociception and food-intake. We therefore considered the hyperphagic obese Zucker rat a good candidate for abnormal responses to nociceptive stimuli. Pairs of lean and obese sisters were tested for latency of response to nociceptive stimuli by tail-flick and tail-pinch methods. Obese rats exhibited shorter latencies in each test, (tail-flick,
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| doi_str_mv | 10.1016/0031-9384(86)90156-3 |
| format | Article |
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p<0.05 and tail-pinch,
p<0.001). Dose/response curves for morphine analgesia indicate that morphine is less potent in obese than in lean rats (ED
50's=4.87±0.62 mg/kg and 3.12±0.41 mg/kg respectively,
p<0.05). These data suggest a defect in the EO systems of obese Zucker rats.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/0031-9384(86)90156-3</identifier><identifier>PMID: 3797488</identifier><language>eng</language><publisher>Cambridge: Elsevier Inc</publisher><subject>Analgesia ; Animals ; Biological and medical sciences ; Eating ; Endogenous opioids ; Endorphins - physiology ; Female ; Medical sciences ; Metabolic diseases ; Morphine ; Nociception ; Obesity ; Obesity - physiopathology ; Pain ; Pain - physiopathology ; Pain Measurement ; Rats ; Rats, Zucker ; Reaction Time - physiology ; Zucker rat</subject><ispartof>Physiology & behavior, 1986, Vol.38 (2), p.215-218</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-adf882e1308ed8f77b3d5cb5f320b59159c130198b8ff400fbc6fa6b21691b4a3</citedby><cites>FETCH-LOGICAL-c417t-adf882e1308ed8f77b3d5cb5f320b59159c130198b8ff400fbc6fa6b21691b4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0031938486901563$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27902,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8157516$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3797488$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roane, David S.</creatorcontrib><creatorcontrib>Porter, Johnny R.</creatorcontrib><title>Nociception and opioid-induced analgesia in lean (Fa/−) and obese (fa/fa) Zucker rats</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>Previous research indicates a possible interrelationship between the endogenous opioids (EO), nociception and food-intake. We therefore considered the hyperphagic obese Zucker rat a good candidate for abnormal responses to nociceptive stimuli. Pairs of lean and obese sisters were tested for latency of response to nociceptive stimuli by tail-flick and tail-pinch methods. Obese rats exhibited shorter latencies in each test, (tail-flick,
p<0.05 and tail-pinch,
p<0.001). Dose/response curves for morphine analgesia indicate that morphine is less potent in obese than in lean rats (ED
50's=4.87±0.62 mg/kg and 3.12±0.41 mg/kg respectively,
p<0.05). These data suggest a defect in the EO systems of obese Zucker rats.</description><subject>Analgesia</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Eating</subject><subject>Endogenous opioids</subject><subject>Endorphins - physiology</subject><subject>Female</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Morphine</subject><subject>Nociception</subject><subject>Obesity</subject><subject>Obesity - physiopathology</subject><subject>Pain</subject><subject>Pain - physiopathology</subject><subject>Pain Measurement</subject><subject>Rats</subject><subject>Rats, Zucker</subject><subject>Reaction Time - physiology</subject><subject>Zucker rat</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2KFDEQx4O4rOPqGyj0QWTm0E5q8tkXQRbXXVj0oiheQj4qEu3pHpNuYd_As4_ok5hxhjlqXQL1_1VR_ELIE6AvgIJcU8qg7ZjmSy1XHQUhW3aPLEAr1gqqPt0nixPygDws5SutxTg7J-dMdYprvSAf344-edxNaRwaO4Rm3KUxhTYNYfYYasv2X7Ak26Sh6dEOzfLKrn___LU60A4LNsto19Gums-z_4a5yXYqj8hZtH3Bx8f3gny4ev3-8rq9fffm5vLVbes5qKm1IWq9QWBUY9BRKceC8E5EtqFOdCA6XzPotNMxckqj8zJa6TYgO3Dcsgvy_LB3l8fvM5bJbFPx2Pd2wHEuRqkNoxT4f0HgUtRToIL8APo8lpIxml1OW5vvDFCzF2_2Vs3eqtHS_BVvWB17etw_uy2G09DRdM2fHXNbvO1jtoNP5YRpEEqArNjLA4ZV2o-E2RSfcKhfkTL6yYQx_fuOP3dcna0</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>Roane, David S.</creator><creator>Porter, Johnny R.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>Nociception and opioid-induced analgesia in lean (Fa/−) and obese (fa/fa) Zucker rats</title><author>Roane, David S. ; Porter, Johnny R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-adf882e1308ed8f77b3d5cb5f320b59159c130198b8ff400fbc6fa6b21691b4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Analgesia</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Eating</topic><topic>Endogenous opioids</topic><topic>Endorphins - physiology</topic><topic>Female</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Morphine</topic><topic>Nociception</topic><topic>Obesity</topic><topic>Obesity - physiopathology</topic><topic>Pain</topic><topic>Pain - physiopathology</topic><topic>Pain Measurement</topic><topic>Rats</topic><topic>Rats, Zucker</topic><topic>Reaction Time - physiology</topic><topic>Zucker rat</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roane, David S.</creatorcontrib><creatorcontrib>Porter, Johnny R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roane, David S.</au><au>Porter, Johnny R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nociception and opioid-induced analgesia in lean (Fa/−) and obese (fa/fa) Zucker rats</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1986</date><risdate>1986</risdate><volume>38</volume><issue>2</issue><spage>215</spage><epage>218</epage><pages>215-218</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>Previous research indicates a possible interrelationship between the endogenous opioids (EO), nociception and food-intake. We therefore considered the hyperphagic obese Zucker rat a good candidate for abnormal responses to nociceptive stimuli. Pairs of lean and obese sisters were tested for latency of response to nociceptive stimuli by tail-flick and tail-pinch methods. Obese rats exhibited shorter latencies in each test, (tail-flick,
p<0.05 and tail-pinch,
p<0.001). Dose/response curves for morphine analgesia indicate that morphine is less potent in obese than in lean rats (ED
50's=4.87±0.62 mg/kg and 3.12±0.41 mg/kg respectively,
p<0.05). These data suggest a defect in the EO systems of obese Zucker rats.</abstract><cop>Cambridge</cop><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3797488</pmid><doi>10.1016/0031-9384(86)90156-3</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-9384 |
| ispartof | Physiology & behavior, 1986, Vol.38 (2), p.215-218 |
| issn | 0031-9384 1873-507X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77230014 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Analgesia Animals Biological and medical sciences Eating Endogenous opioids Endorphins - physiology Female Medical sciences Metabolic diseases Morphine Nociception Obesity Obesity - physiopathology Pain Pain - physiopathology Pain Measurement Rats Rats, Zucker Reaction Time - physiology Zucker rat |
| title | Nociception and opioid-induced analgesia in lean (Fa/−) and obese (fa/fa) Zucker rats |
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