Nociception and opioid-induced analgesia in lean (Fa/−) and obese (fa/fa) Zucker rats

Nociception and opioid-induced analgesia in lean (Fa/−) and obese (fa/fa) Zucker rats

Previous research indicates a possible interrelationship between the endogenous opioids (EO), nociception and food-intake. We therefore considered the hyperphagic obese Zucker rat a good candidate for abnormal responses to nociceptive stimuli. Pairs of lean and obese sisters were tested for latency...

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Veröffentlicht in:Physiology & behavior 1986, Vol.38 (2), p.215-218
Hauptverfasser: Roane, David S., Porter, Johnny R.
Format: Artikel
Sprache:eng
Schlagworte:
Analgesia
Animals
Biological and medical sciences
Eating
Endogenous opioids
Endorphins - physiology
Female
Medical sciences
Metabolic diseases
Morphine
Nociception
Obesity
Obesity - physiopathology
Pain
Pain - physiopathology
Pain Measurement
Rats
Rats, Zucker
Reaction Time - physiology
Zucker rat
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Zusammenfassung:Previous research indicates a possible interrelationship between the endogenous opioids (EO), nociception and food-intake. We therefore considered the hyperphagic obese Zucker rat a good candidate for abnormal responses to nociceptive stimuli. Pairs of lean and obese sisters were tested for latency of response to nociceptive stimuli by tail-flick and tail-pinch methods. Obese rats exhibited shorter latencies in each test, (tail-flick, p
ISSN:0031-9384
1873-507X
DOI:10.1016/0031-9384(86)90156-3