Effect of Adrenalectomy on the Pancreas of db/db Mice

Summary Adrenalectomy has been performed in the diabetic mouse and the islet immunohistochemistry studied. Adrenalectomy restored blood glucose to normal. Mean islet size of diabetic animals was larger than that of either adrenalectomized diabetic animals or of lean controls. Adrenalectomy restored...

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Veröffentlicht in:	Hormone and metabolic research 1986-11, Vol.18 (11), p.743-745
Hauptverfasser:	Spear, G. S., Ohshima, K., Bray, G. A., Caple, M. V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenalectomy Animals Biological and medical sciences Body Weight Diabetes Mellitus, Experimental - metabolism Diabetes Mellitus, Experimental - pathology Diabetes. Impaired glucose tolerance Disease Models, Animal Endocrine pancreas. Apud cells (diseases) Endocrinopathies Glucagon - metabolism Histocytochemistry Immunologic Techniques Insulin - metabolism Islets of Langerhans - metabolism Islets of Langerhans - pathology Medical sciences Mice Mice, Inbred C57BL ORIGINALS Somatostatin - metabolism
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Zusammenfassung:	Summary Adrenalectomy has been performed in the diabetic mouse and the islet immunohistochemistry studied. Adrenalectomy restored blood glucose to normal. Mean islet size of diabetic animals was larger than that of either adrenalectomized diabetic animals or of lean controls. Adrenalectomy restored the immunohistochemical appearance of the islets to normal when examinded with anti-insulin, anti-glucagon and anti-somatostatin antisera.
ISSN:	0018-5043 1439-4286
DOI:	10.1055/s-2007-1012424