Myothermal economy of rat myocardium, Chronic adaptation versus acute inotropism

Myothermal economy of rat myocardium, Chronic adaptation versus acute inotropism

By means of rapid planar Hill type antimony-bismuth thermopiles the initial heat liberated by papillary muscles was measured synchronously with developed tension for control (C), pressure-overload (GOP), and hypothyrotic (PTU) rat myocardium (chronic experiments) and after application of 10−6 M isop...

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Veröffentlicht in:Basic research in cardiology 1986, Vol.81 Suppl 1, p.95-102
Hauptverfasser: Holubarsch, Ch, Hasenfuss, G., Blanchard, E., Alpert, N. R., Mulieri, L. A., Just, H.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
catecholamines
hypothyroidism
Hypothyroidism - physiopathology
initial heat
Isoproterenol - pharmacology
Male
Myocardial Contraction - drug effects
Myocardium - metabolism
myothermal economy
positive inotropic drugs
pressure overload
Rats
Rats, Inbred WKY
Stimulation, Chemical
Thermodynamics
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Zusammenfassung:By means of rapid planar Hill type antimony-bismuth thermopiles the initial heat liberated by papillary muscles was measured synchronously with developed tension for control (C), pressure-overload (GOP), and hypothyrotic (PTU) rat myocardium (chronic experiments) and after application of 10−6 M isoproterenol or 200 10−6 M UDCG-115. Economy of force production was analyzed by the ratio of initial heat versus developed tension-time integral. This ratio was found to be reduced by 34% in GOP and by 43% in PTU myocardium (P
ISSN:0300-8428
DOI:10.1007/978-3-662-11374-5_10