Formation of formaldehyde from S-adenosyl-L-[methyl-3H]methionine during enzymic transmethylation of histamine

The experiments described here show that radiolabelled formaldemethone is formed from the radiolabelled methyl group of S-adenosyl-L-methionine in the course of the enzymic conversion of histamine to N tau-methylhistamine in the presence of dimedone suggesting that the formation of HCHO is probably...

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Veröffentlicht in:	FEBS letters 1986-12, Vol.209 (2), p.362-366
Hauptverfasser:	HUSZTI, Z, TYIHAK, E
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Applied sciences Biological and medical sciences Enzymes and enzyme inhibitors Exact sciences and technology Formaldehyde - metabolism Fundamental and applied biological sciences. Psychology Histamine - metabolism Histamine N-Methyltransferase - metabolism Kidney - enzymology Kinetics Methylation Methyltransferases - metabolism Other techniques and industries Rats S-Adenosylmethionine - metabolism Transferases
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Zusammenfassung:	The experiments described here show that radiolabelled formaldemethone is formed from the radiolabelled methyl group of S-adenosyl-L-methionine in the course of the enzymic conversion of histamine to N tau-methylhistamine in the presence of dimedone suggesting that the formation of HCHO is probably linked to the enzymic transmethylation of histamine.
ISSN:	0014-5793 1873-3468