Biomagnetic Neurosensors. 3. Noninvasive Sensors Using Magnetic Stimulation and Biomagnetic Detection

A noninvasive biomagnetic sensor system that uses magnetic toroids for both neural stimulation and detection is described. It is shown that analytical signals obtained by direct magnetic detection (no signal averaging) compare favorably with electrical monitoring and that dose-response curves for lo...

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Veröffentlicht in:	Analytical chemistry (Washington) 1995-02, Vol.67 (4), p.763-769
Hauptverfasser:	Babb, Christopher W, Coon, David R, Rechnitz, Garry A
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials Anesthetics, Local - pharmacology Animals Astacoidea - physiology Biochemistry Biosensing Techniques Biosensors Dose-Response Relationship, Drug Electrodes Magnetics Magnetism Nerve Fibers - drug effects Nerve Fibers - physiology Neurons Sodium Channels - drug effects
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Zusammenfassung:	A noninvasive biomagnetic sensor system that uses magnetic toroids for both neural stimulation and detection is described. It is shown that analytical signals obtained by direct magnetic detection (no signal averaging) compare favorably with electrical monitoring and that dose-response curves for local anesthetics correlate well between the two methods. Neural lifetimes are significantly extended when the noninvasive biomagnetic sensing system is used.
ISSN:	0003-2700 1520-6882
DOI:	10.1021/ac00100a012