Polymorphism of the pentanucleotide repeat d(AAAAT) within intron 1 of the human tumor suppressor gene p53 (17p13.1)

DyeDeoxy terminator cycle sequencing of allele-specific polymerase chain reaction products has shown that there is a highly polymorphic d(AAAAT) pentanucleotide repeat within the first intron of the human p53 gene. This provides a genetic marker for tumor suppressor p53 gene alterations.

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Bibliographische Detailangaben
Veröffentlicht in:	Human genetics 1995-04, Vol.95 (4), p.471-472
Hauptverfasser:	HAHN, M, FISLAGE, R, PINGOUD, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Base Sequence Biological and medical sciences Chromosome Mapping Chromosomes, Human, Pair 17 Classical genetics, quantitative genetics, hybrids DNA Primers - chemistry Fundamental and applied biological sciences. Psychology Gene Frequency Genes, p53 - genetics Genetic Markers Genetics of eukaryotes. Biological and molecular evolution Human Humans Introns - genetics man Molecular Sequence Data nucleotide sequence p53 gene Polymerase Chain Reaction polymorphism Polymorphism, Genetic - genetics repeated sequence Repetitive Sequences, Nucleic Acid tumor suppressor genes
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Beschreibung
Zusammenfassung:	DyeDeoxy terminator cycle sequencing of allele-specific polymerase chain reaction products has shown that there is a highly polymorphic d(AAAAT) pentanucleotide repeat within the first intron of the human p53 gene. This provides a genetic marker for tumor suppressor p53 gene alterations.
ISSN:	0340-6717 1432-1203
DOI:	10.1007/BF00208983