Decreased rat adrenal 21-hydroxylase activity associated with decreased adrenal microsomal cytochrome P-450 after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin
This study was undertaken to examine the activity of adrenal 21-hydroxylase in the rat following exposure to TCDD. Since 21-hydroxylase is an adrenal microsomal cytochrome P-450-dependent enzyme, and TCDD has been reported to cause decreases in testicular microsomal cytochrome P-450, the concentrati...
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| Veröffentlicht in: | Biochemical pharmacology 1986-12, Vol.35 (24), p.4359-4362 |
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| container_end_page | 4362 |
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| container_issue | 24 |
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| container_title | Biochemical pharmacology |
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| creator | Mebus, Charles A. Piper, Walter N. |
| description | This study was undertaken to examine the activity of adrenal 21-hydroxylase in the rat following exposure to TCDD. Since 21-hydroxylase is an adrenal microsomal cytochrome P-450-dependent enzyme, and TCDD has been reported to cause decreases in testicular microsomal cytochrome P-450, the concentration of adrenal microsomal cytochrome P450 was also determined. |
| doi_str_mv | 10.1016/0006-2952(86)90748-3 |
| format | Article |
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Since 21-hydroxylase is an adrenal microsomal cytochrome P-450-dependent enzyme, and TCDD has been reported to cause decreases in testicular microsomal cytochrome P-450, the concentration of adrenal microsomal cytochrome P450 was also determined.</description><subject>Adrenal Glands - drug effects</subject><subject>Adrenal Glands - enzymology</subject><subject>Animals</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>Dioxins - pharmacology</subject><subject>Exact sciences and technology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microsomes - enzymology</subject><subject>Other techniques and industries</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Polychlorinated Dibenzodioxins - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Steroid 21-Hydroxylase - metabolism</subject><subject>Steroid Hydroxylases - metabolism</subject><subject>Toxicology</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuLFDEUhYMoYzv6DxSyEFHoaFJ51kaQ8QkDutB1SCe36EhVpU3SY5f_xn9qld320lnlcb5zuNyD0GNGXzLK1CtKqSJNK5vnRr1oqRaG8DtoxYzm87cyd9HqjNxHD0r5vjyNYhfogouWKcZW6Pdb8BlcgYCzq9iFDKPrccPIdgo5HaZ-1rDzNd7EOmFXSvLR1Rn_GesWh7P7n3OIPqeShvnqp5r8NqcB8BciJMWuq5AxHHap7DPgmnCz5mu9NqRCzc5v-5RTiBsYfyWyIyGmQxwfonud6ws8Op2X6Nv7d1-vPpLrzx8-Xb25Jl4IVUmnKKc8GGqCd1QqrpWXmguqlGFacs2Y7JzRSmnZhVaFjZHcUM3AdayRLb9Ez465u5x-7KFUO8Tioe_dCGlfrNasbYUwt4JMKM14o2dQHMFlIyVDZ3c5Di5PllG7VGiXQuzSjzXK_q3Q8tn25JS_3wwQzqZTZ7P-9KS74l3fZTf6WM6Y4UrO1O0YbSld0l4fMZh3exMh2-IjjB5CzOCrDSn-f9w_uFnEHg</recordid><startdate>19861215</startdate><enddate>19861215</enddate><creator>Mebus, Charles A.</creator><creator>Piper, Walter N.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19861215</creationdate><title>Decreased rat adrenal 21-hydroxylase activity associated with decreased adrenal microsomal cytochrome P-450 after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin</title><author>Mebus, Charles A. ; Piper, Walter N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-f60303d808dca056376c5734066817537115fa876675fd96db8538071eaf12593</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adrenal Glands - drug effects</topic><topic>Adrenal Glands - enzymology</topic><topic>Animals</topic><topic>Applied sciences</topic><topic>Biological and medical sciences</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>Dioxins - pharmacology</topic><topic>Exact sciences and technology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microsomes - enzymology</topic><topic>Other techniques and industries</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Polychlorinated Dibenzodioxins - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Steroid 21-Hydroxylase - metabolism</topic><topic>Steroid Hydroxylases - metabolism</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mebus, Charles A.</creatorcontrib><creatorcontrib>Piper, Walter N.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mebus, Charles A.</au><au>Piper, Walter N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased rat adrenal 21-hydroxylase activity associated with decreased adrenal microsomal cytochrome P-450 after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1986-12-15</date><risdate>1986</risdate><volume>35</volume><issue>24</issue><spage>4359</spage><epage>4362</epage><pages>4359-4362</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><coden>BCPCA6</coden><abstract>This study was undertaken to examine the activity of adrenal 21-hydroxylase in the rat following exposure to TCDD. Since 21-hydroxylase is an adrenal microsomal cytochrome P-450-dependent enzyme, and TCDD has been reported to cause decreases in testicular microsomal cytochrome P-450, the concentration of adrenal microsomal cytochrome P450 was also determined.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>3491611</pmid><doi>10.1016/0006-2952(86)90748-3</doi><tpages>4</tpages></addata></record> |
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| ispartof | Biochemical pharmacology, 1986-12, Vol.35 (24), p.4359-4362 |
| issn | 0006-2952 1873-2968 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adrenal Glands - drug effects Adrenal Glands - enzymology Animals Applied sciences Biological and medical sciences Cytochrome P-450 Enzyme System - metabolism Dioxins - pharmacology Exact sciences and technology Male Medical sciences Microsomes - enzymology Other techniques and industries Pesticides, fertilizers and other agrochemicals toxicology Polychlorinated Dibenzodioxins - pharmacology Rats Rats, Inbred Strains Steroid 21-Hydroxylase - metabolism Steroid Hydroxylases - metabolism Toxicology |
| title | Decreased rat adrenal 21-hydroxylase activity associated with decreased adrenal microsomal cytochrome P-450 after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin |
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