Decreased rat adrenal 21-hydroxylase activity associated with decreased adrenal microsomal cytochrome P-450 after exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin

This study was undertaken to examine the activity of adrenal 21-hydroxylase in the rat following exposure to TCDD. Since 21-hydroxylase is an adrenal microsomal cytochrome P-450-dependent enzyme, and TCDD has been reported to cause decreases in testicular microsomal cytochrome P-450, the concentrati...

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Veröffentlicht in:	Biochemical pharmacology 1986-12, Vol.35 (24), p.4359-4362
Hauptverfasser:	Mebus, Charles A., Piper, Walter N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - drug effects Adrenal Glands - enzymology Animals Applied sciences Biological and medical sciences Cytochrome P-450 Enzyme System - metabolism Dioxins - pharmacology Exact sciences and technology Male Medical sciences Microsomes - enzymology Other techniques and industries Pesticides, fertilizers and other agrochemicals toxicology Polychlorinated Dibenzodioxins - pharmacology Rats Rats, Inbred Strains Steroid 21-Hydroxylase - metabolism Steroid Hydroxylases - metabolism Toxicology
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Beschreibung
Zusammenfassung:	This study was undertaken to examine the activity of adrenal 21-hydroxylase in the rat following exposure to TCDD. Since 21-hydroxylase is an adrenal microsomal cytochrome P-450-dependent enzyme, and TCDD has been reported to cause decreases in testicular microsomal cytochrome P-450, the concentration of adrenal microsomal cytochrome P450 was also determined.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/0006-2952(86)90748-3