Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas

Three triterpenes were isolated from Diospyros leucomelas and identified as betulin, betulinic acid, and ursolic acid. They showed anti-inflammatory activity in the carrageenan and serotonin paw edema tests and TPA and EPP ear edema tests. The blockade of their effects by progesterone, actinomycin D...

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Veröffentlicht in:	Planta medica 1995-02, Vol.61 (1), p.9-12
Hauptverfasser:	Carmen Recio, M. del, Giner, R.M, Manez, S, Gueho, J, Julien, H.R, Hostettmann, K, Rios, J.L. (Valencia Univ. (Spain). Facultat de Farmacia. Dept. de Farmacologia)
Format:	Artikel
Sprache:	eng
Schlagworte:	actinomycin D Animals Anti-Inflammatory Agents - pharmacology Betulinic Acid COMPOSICION QUIMICA COMPOSITION CHIMIQUE cycloheximide DIOSPYROS Diospyros leucomelas Ebenaceae EXPERIMENTACION IN VIVO EXPERIMENTATION IN VIVO FARMACOLOGIA Female in vivo anti-inflammatory activity Mice Pentacyclic Triterpenes Pflanzenbau PHARMACOLOGIE PLANTAS MEDICINALES PLANTE MEDICINALE Plants, Medicinal - chemistry PROGESTERONA PROGESTERONE PROPIEDADES ANTIMICROBIANAS PROPRIETE ANTIMICROBIENNE Steroids triterpenes Triterpenes - pharmacology TRITERPENOIDE TRITERPENOIDOS Ursolic Acid
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Zusammenfassung:	Three triterpenes were isolated from Diospyros leucomelas and identified as betulin, betulinic acid, and ursolic acid. They showed anti-inflammatory activity in the carrageenan and serotonin paw edema tests and TPA and EPP ear edema tests. The blockade of their effects by progesterone, actinomycin D, and cycloheximide has served to determine the mechanism of action in relationship with that of glucocorticoids. Betulinic acid was the most affected and therefore a mode of action similar to these drugs may be postulated for it.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2006-957988