Labdane Diterpenoid Glycosides from Alpinia densespicata and Their Nitric Oxide Inhibitory Activities in Macrophages

Four new labdane diterpene glycosides (1−4) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (7−9) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 1−6 was b...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2009-06, Vol.72 (6), p.1097-1101
Hauptverfasser:	Kuo, Yu-Jen, Hsiao, Ping-Chun, Zhang, Li-Jie, Wu, Ming-Der, Liang, Yu-Han, Ho, Hsiu-O, Kuo, Yao-Haur
Format:	Artikel
Sprache:	eng
Schlagworte:	alpindenosides Alpinia Alpinia - chemistry Alpinia densespicata Animals anti-inflammatory activity Biological and medical sciences chemical constituents of plants chemical structure cytotoxicity Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology diterpenoids Drug Screening Assays, Antitumor Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology General pharmacology glycosides Glycosides - chemistry Glycosides - pharmacology HeLa Cells human cell lines Humans KB Cells labdane diterpenoids Lipopolysaccharides - pharmacology macrophages Macrophages - drug effects Medical sciences medicinal properties Mice Molecular Structure neoplasms nitric oxide Nitric Oxide - antagonists & inhibitors noralpindenosides Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phytochemicals spectroscopy stems
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Zusammenfassung:	Four new labdane diterpene glycosides (1−4) named alpindenosides A, B, C, and D, two new norditerpene glycosides (5, 6) named noralpindenosides A and B, and three known flavonoid glycosides (7−9) have been isolated from the stems of Alpinia densespicata. Structural elucidation of compounds 1−6 was based on spectroscopic data. Compounds 1−9 all exhibited moderate NO inhibitory activities, whereas they were noncytotoxic at 20 μM against several human tumor cell lines.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np900019n