A diterpene from Mikania obtusata active on Trypanosoma cruzi

The diterpene ent-kaur-16-en-19-oic acid was identified as the trypanocidal component of the ethanolic extract from Mikaniaobtusata D. C. (Asteraceae). This compound presents an IC50 of 0.5mg/ml (1.66 mM) against the trypomastigote blood form of the Trypanosoma cruzi, the causative agent of Chagas&#...

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Veröffentlicht in:	Planta medica 1995-02, Vol.61 (1), p.85-87
Hauptverfasser:	Alves, T.M.A, Chaves, P.P.G, Santos, L.M.S.T, Nagem, T.J, Murta, S.M.F, Ceravolo, I.P, Romanha, A.J, Zani, C.L. (Centro de Pesquisas "Rene Rachou", Belo Horizonte (Brazil). Lab. de Quimica de Produtos Naturais)
Format:	Artikel
Sprache:	eng
Schlagworte:	aerial parts Animals Asteraceae Biological and medical sciences COMPOSICION QUIMICA COMPOSITION CHIMIQUE diterpenes Diterpenes - pharmacology ESTRUCTURA QUIMICA FARMACOLOGIA General pharmacology Letter Medical sciences Mice MIKANIA Mikania obtusata ORGANOS AEREOS PARTIE AERIENNE Pflanzenbau Pharmacognosy. Homeopathy. Health food PHARMACOLOGIE Pharmacology. Drug treatments PLANTAS MEDICINALES PLANTE MEDICINALE Plants - chemistry STRUCTURE CHIMIQUE TRIPANOSOMIASIS Trypanocidal Agents - pharmacology TRYPANOSOMA CRUZI Trypanosoma cruzi - drug effects TRYPANOSOMOSE
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Beschreibung
Zusammenfassung:	The diterpene ent-kaur-16-en-19-oic acid was identified as the trypanocidal component of the ethanolic extract from Mikaniaobtusata D. C. (Asteraceae). This compound presents an IC50 of 0.5mg/ml (1.66 mM) against the trypomastigote blood form of the Trypanosoma cruzi, the causative agent of Chagas' disease (American trypanosomiasis).
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2006-958011