Cardenolides from Saussurea stella with Cytotoxicity toward Cancer Cells

Three new cardenolides, 3-O-β-d-fucopyranosylstrophanthidin (1), 3-O-β-d-quinovopyranosylperiplogenin (2), and 3-O-β-d-glucopyranosyl-(1→4)-α-l-rhamnopyranosylcannogenin (3), together with seven known cardenolides (4–10), were isolated from a cytotoxic ethanol extract of the whole dried plants of Saussurea stella. The structures of these compounds were established by spectroscopic and chemical methods. When the cytotoxicity of compounds 2–10 toward Bel-7402 human hepatoma cells and BGC-823 human gastric cancer cells was evaluated, all compounds showed IC50 values of