The predictive value of maternal serum testing for detection of fetal anemia in red blood cell alloimmunization

OBJECTIVE: Current management protocols for pregnancies complicated by red blood cell alloimmunization use the maternal antibody titer to predict the need for invasive testing for detection fetal anemia. We investigated the use of three maternal serum tests to assess their usefulness in predicting f...

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Veröffentlicht in:American journal of obstetrics and gynecology 1995-03, Vol.172 (3), p.1003-1009
Hauptverfasser: Moise Jr, Kenneth J., Perkins, James T., Sosler, Steven D., Brown, Susan J., Saade, George, Carpenter, Robert J., Thorp, James A., Ludomirski, Avi, Wilkins, Isabelle A., Grannum, Peter A., Copel, Joshua
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Sprache:eng
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Zusammenfassung:OBJECTIVE: Current management protocols for pregnancies complicated by red blood cell alloimmunization use the maternal antibody titer to predict the need for invasive testing for detection fetal anemia. We investigated the use of three maternal serum tests to assess their usefulness in predicting fetal disease: indirect Coombs' titer, Marsh score, and monocyte monolayer assay. STUDY DESIGN: Foryt-seven serum samples from pregnant women with red blood cell antibodies associated with fetal anemia were analyzed at cordocentesis. Fetal blood was analyzed for hematocrit (correlated for gestational age) and antigen status. Fetal anemia was defined as a hematocrit value of
ISSN:0002-9378
1097-6868
DOI:10.1016/0002-9378(95)90034-9