Cardiotonic agents. 4. Synthesis and biological evaluation of N-substituted 2,4,4a,5-tetrahydro-3H-indeno[1,2-c]pyridazin-3-ones: rigid structures derived from CI-930 and analogs
Several N-substituted 3H-indeno[1,2-c]pyridazinones (1-23) and a benzo[h]cinnolinone (24), which were designed as rigid structural modifications of 5-alkyl-4,5-dihydro-6-[4-N-substituted phenyl]-3(2H)-pyridazinones (ib-d), were synthesized and evaluated for positive inotropic activity. Most of these...
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| Veröffentlicht in: | Journal of medicinal chemistry 1986-11, Vol.29 (11), p.2142-2148 |
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| container_end_page | 2148 |
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| container_issue | 11 |
| container_start_page | 2142 |
| container_title | Journal of medicinal chemistry |
| container_volume | 29 |
| creator | Sircar, Ila Duell, Bradley L Cain, Michael H Burke, Sandra E Bristol, James A |
| description | Several N-substituted 3H-indeno[1,2-c]pyridazinones (1-23) and a benzo[h]cinnolinone (24), which were designed as rigid structural modifications of 5-alkyl-4,5-dihydro-6-[4-N-substituted phenyl]-3(2H)-pyridazinones (ib-d), were synthesized and evaluated for positive inotropic activity. Most of these tricyclic pyridazinones (1-11, 14-15, 22-23) demonstrated potent positive inotropic activity comparable to the corresponding phenylpyridazinones related to I. |
| doi_str_mv | 10.1021/jm00161a003 |
| format | Article |
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| ispartof | Journal of medicinal chemistry, 1986-11, Vol.29 (11), p.2142-2148 |
| issn | 0022-2623 1520-4804 |
| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Cardiotonic Agents - chemical synthesis Cardiotonic Agents - pharmacology Dogs Female Male Myocardial Contraction - drug effects Pyridazines - chemical synthesis Pyridazines - pharmacology Structure-Activity Relationship |
| title | Cardiotonic agents. 4. Synthesis and biological evaluation of N-substituted 2,4,4a,5-tetrahydro-3H-indeno[1,2-c]pyridazin-3-ones: rigid structures derived from CI-930 and analogs |
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