Cardiotonic agents. 4. Synthesis and biological evaluation of N-substituted 2,4,4a,5-tetrahydro-3H-indeno[1,2-c]pyridazin-3-ones: rigid structures derived from CI-930 and analogs

Cardiotonic agents. 4. Synthesis and biological evaluation of N-substituted 2,4,4a,5-tetrahydro-3H-indeno[1,2-c]pyridazin-3-ones: rigid structures derived from CI-930 and analogs

Several N-substituted 3H-indeno[1,2-c]pyridazinones (1-23) and a benzo[h]cinnolinone (24), which were designed as rigid structural modifications of 5-alkyl-4,5-dihydro-6-[4-N-substituted phenyl]-3(2H)-pyridazinones (ib-d), were synthesized and evaluated for positive inotropic activity. Most of these...

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Veröffentlicht in:Journal of medicinal chemistry 1986-11, Vol.29 (11), p.2142-2148
Hauptverfasser: Sircar, Ila, Duell, Bradley L, Cain, Michael H, Burke, Sandra E, Bristol, James A
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cardiotonic Agents - chemical synthesis
Cardiotonic Agents - pharmacology
Dogs
Female
Male
Myocardial Contraction - drug effects
Pyridazines - chemical synthesis
Pyridazines - pharmacology
Structure-Activity Relationship
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Zusammenfassung:Several N-substituted 3H-indeno[1,2-c]pyridazinones (1-23) and a benzo[h]cinnolinone (24), which were designed as rigid structural modifications of 5-alkyl-4,5-dihydro-6-[4-N-substituted phenyl]-3(2H)-pyridazinones (ib-d), were synthesized and evaluated for positive inotropic activity. Most of these tricyclic pyridazinones (1-11, 14-15, 22-23) demonstrated potent positive inotropic activity comparable to the corresponding phenylpyridazinones related to I.
ISSN:0022-2623
1520-4804
DOI:10.1021/jm00161a003