Neuroprotective Bibenzyl Glycosides of Stemona tuberosa Roots

Three new bibenzyl glycosides characterized as stilbostemin B 3'-beta-D-glucopyranoside (1), stilbostemin H 3'-beta-D-glucopyranoside (2), and stilbostemin I 2"-beta-D-glucopyranoside (3) were isolated from the roots of Stemona tuberosa. All three bibenzyl glycosides significantly pro...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2006-04, Vol.69 (4), p.679-681
Hauptverfasser:	Lee, K.Y, Sung, S.H, Kim, Y.C
Format:	Artikel
Sprache:	eng
Schlagworte:	Bibenzyls - chemistry Bibenzyls - isolation & purification Bibenzyls - pharmacology Biological and medical sciences chemical structure cultured cells General pharmacology glycosides Glycosides - chemistry Glycosides - isolation & purification Glycosides - pharmacology Humans Korea Medical sciences medicinal plants medicinal properties Molecular Structure Neuroprotective Agents - chemistry Neuroprotective Agents - isolation & purification Neuroprotective Agents - pharmacology neuroprotective effect neurotoxicity Neurotoxicity Syndromes Oriental traditional medicine Oxidopamine - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments plant extracts Plant Roots - chemistry Plants, Medicinal - chemistry roots Stemona Stemona tuberosa Stemonaceae - chemistry stibostemin Tumor Cells, Cultured
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Zusammenfassung:	Three new bibenzyl glycosides characterized as stilbostemin B 3'-beta-D-glucopyranoside (1), stilbostemin H 3'-beta-D-glucopyranoside (2), and stilbostemin I 2"-beta-D-glucopyranoside (3) were isolated from the roots of Stemona tuberosa. All three bibenzyl glycosides significantly protected human neuroblastoma SH-SY5Y cells from 6-hydroxydopamine-induced neurotoxicity.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np0504154