ent-Kaurane Diterpenoids from Isodon albopilosus

Nine new diterpenoids, albopilosins B−J (1−9), together with six known analogues, albopilosin A (10), macrocalyxin C (11), rabdokunmin C (12), excisanin (13), amethystonoic acid (14), and coetsanoic acid (15), were isolated from the aerial parts of Isodon albopilosus. The structures of 1−9 were esta...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-12, Vol.68 (12), p.1758-1762
Hauptverfasser:	Huang, Sheng-Xiong, Zhao, Qin-Shi, Xu, Gang, Xiao, Wei-Lie, Li, Rong-Tao, Hou, Ai-Jun, Peng, Shu-Lin, Ding, Li-Sheng, Sun, Han-Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	albopilosins anticarcinogenic activity Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences chemical structure cultured cells cytotoxicity Diterpenes, Kaurane - chemistry Diterpenes, Kaurane - isolation & purification Diterpenes, Kaurane - pharmacology diterpenoids Drug Screening Assays, Antitumor Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - isolation & purification Drugs, Chinese Herbal - pharmacology General pharmacology Humans Inhibitory Concentration 50 Isodon Isodon - chemistry Isodon albopilosus kaurane Medical sciences Molecular Structure Nuclear Magnetic Resonance, Biomolecular Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry spectral analysis stereochemistry Stereoisomerism Tumor Cells, Cultured
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Zusammenfassung:	Nine new diterpenoids, albopilosins B−J (1−9), together with six known analogues, albopilosin A (10), macrocalyxin C (11), rabdokunmin C (12), excisanin (13), amethystonoic acid (14), and coetsanoic acid (15), were isolated from the aerial parts of Isodon albopilosus. The structures of 1−9 were established using spectroscopic methods including extensive 1D and 2D NMR analysis. The diterpenoids isolated were evaluated for their inhibitory activities against HepG2 (hepatoma) cells. Compounds 7 and 13 were the most active, with both having IC50 values of
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np050342o