Regional localisations and linkage relationships of seven RFLPs and myotonic dystrophy on chromosome 19

We have studied the genetic linkage relationships of seven DNA polymorphisms on chromosome 19, with each other and with the myotonic dystrophy locus. The DNA sequences were localised to various regions of the chromosome using translocations in somatic cell hybrids. These results provide the basis fo...

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Veröffentlicht in:	Human genetics 1986-11, Vol.74 (3), p.262-266
Hauptverfasser:	SHAW, D. J, MEREDITH, A. L, SARFARAZI, M, HARLEY, H. G, HUSON, S. M, BROOK, J. D, BUFTON, L, LITT, M, MOHANDAS, T, HARPER, P. S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chromosome Mapping Chromosomes, Human, Pair 19 - ultrastructure Diseases of striated muscles. Neuromuscular diseases DNA Female Genetic Linkage Genetic Markers Humans Hybrid Cells - analysis Male Medical sciences Mice Myotonic Dystrophy - diagnosis Myotonic Dystrophy - genetics Neurology Polymorphism, Genetic Polymorphism, Restriction Fragment Length Translocation, Genetic
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Zusammenfassung:	We have studied the genetic linkage relationships of seven DNA polymorphisms on chromosome 19, with each other and with the myotonic dystrophy locus. The DNA sequences were localised to various regions of the chromosome using translocations in somatic cell hybrids. These results provide the basis for a linkage map of most of chromosome 19, and suggest that the myotonic dystrophy locus is close to the centromere.
ISSN:	0340-6717 1432-1203
DOI:	10.1007/BF00282545