ENZYMATIC CONVERSION OF 7-HYDROXYGUANINE TO ITS NUCLEOSIDES

7-Hydroxyguanine, an antitumor purine-analog, reacted with ribose (or deoxyribose)-1-phosphate in the presence of purine nucleoside phosphorylase. We prepared 7-hydroxyguanine riboside and deoxyriboside using purine nucleoside phosphorylase from bovine spleen. Each nucleoside exhibits antitumor acti...

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Veröffentlicht in:	Journal of antibiotics 1986, Vol.39(9), pp.1288-1290
Hauptverfasser:	KITAHARA, MIKIO, ISHII, KIYOTO, OKAZAKI, TAKESHI, HIDAKA, TAKAYOSHI, WATANABE, KIYOSHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Biological and medical sciences Chemical Phenomena Chemistry General pharmacology Guanine - analogs & derivatives Guanine - metabolism Guanine - pharmacology Medical sciences Mice Nucleosides - pharmacology Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships
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Zusammenfassung:	7-Hydroxyguanine, an antitumor purine-analog, reacted with ribose (or deoxyribose)-1-phosphate in the presence of purine nucleoside phosphorylase. We prepared 7-hydroxyguanine riboside and deoxyriboside using purine nucleoside phosphorylase from bovine spleen. Each nucleoside exhibits antitumor activity against mouse leukemia L1210 cells. The therapeutic effect of 7-hydroxyguanine deoxyriboside is superior to those of 7-hydroxyguanine and 7-hydroxyguanine riboside.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.39.1288