Diastereomeric Quinolinone Alkaloids from the Marine-Derived Fungus Penicillium janczewskii

From Penicillium janczewskii, obtained from a marine sample, two new diastereomeric quinolinones, 3S,4R-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (1) and 3R,4R-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (2), were identified, along with two known alkaloi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2005-09, Vol.68 (9), p.1397-1399
Hauptverfasser:	HE, Jian, LION, Ulrich, SATTLER, Isabel, GOLLMICK, Friedrich A., GRABLEY, Susanne, CAI, Jingmin, MEINERS, Marinus, SCHüNKE, Henning, SCHAUMANN, Karsten, DECHERT, Ute, KROHN, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology Biological and medical sciences Drug Screening Assays, Antitumor General pharmacology Humans Marine Marine Biology Medical sciences Molecular Structure North Sea Penicillium - chemistry Penicillium janczewskii Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Quinolones - chemistry Quinolones - isolation & purification Quinolones - pharmacology Stereoisomerism Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	From Penicillium janczewskii, obtained from a marine sample, two new diastereomeric quinolinones, 3S,4R-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (1) and 3R,4R-dihydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (2), were identified, along with two known alkaloids, peniprequinolone (3) and 3-methoxy-4-hydroxy-4-(4'-methoxyphenyl)-3,4-dihydro-2(1H)-quinolinone (4). Cytotoxicity testing on eight tumor cell lines revealed a moderate specificity of 2 on SKOV-3 cells.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np058018g