Cloning and expression of human apolipoprotein D cDNA

Cloning and expression of human apolipoprotein D cDNA

The amino acid sequence of human apolipoprotein D, a component of high density lipoprotein, has been obtained from the cloned cDNA sequence. The 169-amino acid protein has no marked similarity to other apolipoprotein sequences, but has a high degree of homology to plasma retinol-binding protein and...

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Veröffentlicht in:The Journal of biological chemistry 1986-12, Vol.261 (35), p.16535-16539
Hauptverfasser: Drayna, D, Fielding, C, McLean, J, Baer, B, Castro, G, Chen, E, Comstock, L, Henzel, W, Kohr, W, Rhee, L
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Sequence
Apolipoproteins - blood
Apolipoproteins - genetics
Apolipoproteins D
Base Sequence
Biological and medical sciences
Biotechnology
Cloning, Molecular
DNA - metabolism
Fundamental and applied biological sciences. Psychology
Genetic engineering
Genetic technics
Humans
Methods. Procedures. Technologies
Molecular cloning
Molecular Weight
Transcription, Genetic
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Zusammenfassung:The amino acid sequence of human apolipoprotein D, a component of high density lipoprotein, has been obtained from the cloned cDNA sequence. The 169-amino acid protein has no marked similarity to other apolipoprotein sequences, but has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2u-globulin protein superfamily. Apolipoprotein D mRNA has been detected in human liver, intestine, pancreas, kidney, placenta, adrenal, spleen, and fetal brain tissue. Tissue culture cells transfected with the cloned cDNA secrete material that reacts with anti-apoD antibodies.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(18)66599-8