Effect of cacao liquor extract on tumor marker enzymes during chemical hepatocarcinogenesis in rats

This study investigated the effect of cacao liquor extract (CLE) on tumor marker enzymes--alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), glutathione-S-transferase (GST), and glutathione reductase (GR) activities--in plasma and/or liver of hepatocarcinogenic rats, which were induced...

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Veröffentlicht in:	Journal of medicinal food 2004-04, Vol.7 (1), p.7-12
Hauptverfasser:	Amin, I, Koh, B K, Asmah, R
Format:	Artikel
Sprache:	eng
Schlagworte:	2-Acetylaminofluorene Alkaline Phosphatase - metabolism Analysis of Variance Animals Biomarkers, Tumor - blood Cacao Cell Transformation, Neoplastic - drug effects Diethylnitrosamine gamma-Glutamyltransferase - metabolism Glutathione Reductase - metabolism Glutathione Transferase - metabolism Liver - enzymology Liver Neoplasms, Experimental - chemically induced Liver Neoplasms, Experimental - drug therapy Liver Neoplasms, Experimental - enzymology Male Phytotherapy Plant Extracts - therapeutic use Random Allocation Rats Rats, Sprague-Dawley Severity of Illness Index
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Zusammenfassung:	This study investigated the effect of cacao liquor extract (CLE) on tumor marker enzymes--alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), glutathione-S-transferase (GST), and glutathione reductase (GR) activities--in plasma and/or liver of hepatocarcinogenic rats, which were induced with diethylnitrosamine and 2-acetylaminofluorene. Twenty-nine male Sprague-Dawley rats (weighing 150-330 g) were divided into four groups (n = 6-8): normal control group (N), normal group + CLE (NE), cancer group (C), and cancer group + CLE (CE). Analysis of variance showed significant differences (P
ISSN:	1096-620X 1557-7600
DOI:	10.1089/109662004322984635