6-Amino-6-deoxyascorbic acid induces apoptosis in human tumor cells

6-Amino-6-deoxyascorbic acid was found to inhibit human tumor cell growth. The antitumor effect depends on the tumor type and concentration of the acid. After cell treatment with 6-amino-6-deoxyascorbic acid, drastic morphological changes were found. Although image analysis did not show a difference...

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Veröffentlicht in:	Journal of cancer research and clinical oncology 1995-02, Vol.121 (2), p.98-102
Hauptverfasser:	GRDISA, M, KRALJ, M, ECKERT-MAKSIC, M, MAKSIC, Z. B, PAVELIC, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis - drug effects Ascorbic Acid - analogs & derivatives Ascorbic Acid - pharmacology Biological and medical sciences DNA - metabolism General aspects Humans Medical sciences Neoplasms - pathology Pharmacology. Drug treatments Proto-Oncogene Proteins c-myc - analysis Tumor Cells, Cultured Tumor Suppressor Protein p53 - analysis
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Zusammenfassung:	6-Amino-6-deoxyascorbic acid was found to inhibit human tumor cell growth. The antitumor effect depends on the tumor type and concentration of the acid. After cell treatment with 6-amino-6-deoxyascorbic acid, drastic morphological changes were found. Although image analysis did not show a difference in p53 and c-myc gene expression, the appearance of chromatin aggregation and DNA fragmentation points to apoptosis or programmed cell death.
ISSN:	0171-5216 1432-1335
DOI:	10.1007/BF01202220