The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins
Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K + ) channel, I KACh . Activated muscarinic receptors stimulate l KAch via the G-protein βγ-subunits. It has been assumed that the inwardly rectifying K + -channel gene, GIRK1 , alone encodes I KAch -It is no...
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| Veröffentlicht in: | Nature (London) 1995-03, Vol.374 (6518), p.135-141 |
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| container_issue | 6518 |
| container_start_page | 135 |
| container_title | Nature (London) |
| container_volume | 374 |
| creator | Krapivinsky, G. Gordon, E. A. Wickman, K. Velimirović, B. Krapivinsky, L. Clapham, D. E. |
| description | Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K
+
) channel, I
KACh
. Activated muscarinic receptors stimulate l
KAch
via the G-protein βγ-subunits. It has been assumed that the inwardly rectifying K
+
-channel gene,
GIRK1
, alone encodes I
KAch
-It is now shown that I
KAch
is a heteromultimer of two distinct inwardly rectifying K
+
-channel subunits, GIRK1 and a newly cloned member of the family, CIR. |
| doi_str_mv | 10.1038/374135a0 |
| format | Article |
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+
) channel, I
KACh
. Activated muscarinic receptors stimulate l
KAch
via the G-protein βγ-subunits. It has been assumed that the inwardly rectifying K
+
-channel gene,
GIRK1
, alone encodes I
KAch
-It is now shown that I
KAch
is a heteromultimer of two distinct inwardly rectifying K
+
-channel subunits, GIRK1 and a newly cloned member of the family, CIR.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/374135a0</identifier><identifier>PMID: 7877685</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amino Acid Sequence ; Animals ; Biological and medical sciences ; Cell Line ; Cloning, Molecular ; Dogs ; Fundamental and applied biological sciences. Psychology ; G Protein-Coupled Inwardly-Rectifying Potassium Channels ; GTP-Binding Proteins - metabolism ; Heart ; Humanities and Social Sciences ; Ion Channel Gating ; Membrane Potentials ; Molecular Sequence Data ; multidisciplinary ; Myocardium - metabolism ; Oocytes ; Potassium Channels - chemistry ; Potassium Channels - genetics ; Potassium Channels - metabolism ; Potassium Channels, Inwardly Rectifying ; Protein Conformation ; Rats ; Recombinant Proteins ; Science ; Science (multidisciplinary) ; Vertebrates: cardiovascular system ; Xenopus</subject><ispartof>Nature (London), 1995-03, Vol.374 (6518), p.135-141</ispartof><rights>Springer Nature Limited 1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3220-6eb9744a96e339ca114606243cd14f93999af86519c840c3ef579edb712bfec33</citedby><cites>FETCH-LOGICAL-c3220-6eb9744a96e339ca114606243cd14f93999af86519c840c3ef579edb712bfec33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/374135a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/374135a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3436820$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7877685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krapivinsky, G.</creatorcontrib><creatorcontrib>Gordon, E. A.</creatorcontrib><creatorcontrib>Wickman, K.</creatorcontrib><creatorcontrib>Velimirović, B.</creatorcontrib><creatorcontrib>Krapivinsky, L.</creatorcontrib><creatorcontrib>Clapham, D. E.</creatorcontrib><title>The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K
+
) channel, I
KACh
. Activated muscarinic receptors stimulate l
KAch
via the G-protein βγ-subunits. It has been assumed that the inwardly rectifying K
+
-channel gene,
GIRK1
, alone encodes I
KAch
-It is now shown that I
KAch
is a heteromultimer of two distinct inwardly rectifying K
+
-channel subunits, GIRK1 and a newly cloned member of the family, CIR.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cloning, Molecular</subject><subject>Dogs</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>G Protein-Coupled Inwardly-Rectifying Potassium Channels</subject><subject>GTP-Binding Proteins - metabolism</subject><subject>Heart</subject><subject>Humanities and Social Sciences</subject><subject>Ion Channel Gating</subject><subject>Membrane Potentials</subject><subject>Molecular Sequence Data</subject><subject>multidisciplinary</subject><subject>Myocardium - metabolism</subject><subject>Oocytes</subject><subject>Potassium Channels - chemistry</subject><subject>Potassium Channels - genetics</subject><subject>Potassium Channels - metabolism</subject><subject>Potassium Channels, Inwardly Rectifying</subject><subject>Protein Conformation</subject><subject>Rats</subject><subject>Recombinant Proteins</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Vertebrates: cardiovascular system</subject><subject>Xenopus</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkEtLxDAUhYMo4_gA_4CQhYgi1aRJ81gOoqMouBnXJZPezETaVJMWmX9vZTpuXN3F-c534SB0RsktJUzdMckpKwzZQ1PKpci4UHIfTQnJVUYUE4foKKUPQkhBJZ-giVRSClVMUVisAc-zz9h24EO2Mh1U2HTRmxq_3GC7NiFAjZ9fZnaNfcIGr6GD2DZ93fkGIm4d7r5b7MO3iVW9wRFs593Gh9XQz3b90Z9O0IEzdYLT8R6j98eHxf1T9vo2f76fvWaW5TnJBCy15NxoAYxpayjlgoicM1tR7jTTWhunREG1VZxYBq6QGqqlpPnSgWXsGF1uvcPjrx5SVzY-WahrE6DtUyklFazI8wG82oI2tilFcOVn9I2Jm5KS8nfacjftgJ6Pzn7ZQPUHjlsO-cWYm2RN7aIJ1qc_jHEmVP6rud5iaUjCCmL50fYxDGv8f_kDMXuMjA</recordid><startdate>19950309</startdate><enddate>19950309</enddate><creator>Krapivinsky, G.</creator><creator>Gordon, E. A.</creator><creator>Wickman, K.</creator><creator>Velimirović, B.</creator><creator>Krapivinsky, L.</creator><creator>Clapham, D. E.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950309</creationdate><title>The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins</title><author>Krapivinsky, G. ; Gordon, E. A. ; Wickman, K. ; Velimirović, B. ; Krapivinsky, L. ; Clapham, D. E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3220-6eb9744a96e339ca114606243cd14f93999af86519c840c3ef579edb712bfec33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cloning, Molecular</topic><topic>Dogs</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>G Protein-Coupled Inwardly-Rectifying Potassium Channels</topic><topic>GTP-Binding Proteins - metabolism</topic><topic>Heart</topic><topic>Humanities and Social Sciences</topic><topic>Ion Channel Gating</topic><topic>Membrane Potentials</topic><topic>Molecular Sequence Data</topic><topic>multidisciplinary</topic><topic>Myocardium - metabolism</topic><topic>Oocytes</topic><topic>Potassium Channels - chemistry</topic><topic>Potassium Channels - genetics</topic><topic>Potassium Channels - metabolism</topic><topic>Potassium Channels, Inwardly Rectifying</topic><topic>Protein Conformation</topic><topic>Rats</topic><topic>Recombinant Proteins</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Vertebrates: cardiovascular system</topic><topic>Xenopus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Krapivinsky, G.</creatorcontrib><creatorcontrib>Gordon, E. A.</creatorcontrib><creatorcontrib>Wickman, K.</creatorcontrib><creatorcontrib>Velimirović, B.</creatorcontrib><creatorcontrib>Krapivinsky, L.</creatorcontrib><creatorcontrib>Clapham, D. E.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Krapivinsky, G.</au><au>Gordon, E. A.</au><au>Wickman, K.</au><au>Velimirović, B.</au><au>Krapivinsky, L.</au><au>Clapham, D. E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1995-03-09</date><risdate>1995</risdate><volume>374</volume><issue>6518</issue><spage>135</spage><epage>141</epage><pages>135-141</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><coden>NATUAS</coden><abstract>Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K
+
) channel, I
KACh
. Activated muscarinic receptors stimulate l
KAch
via the G-protein βγ-subunits. It has been assumed that the inwardly rectifying K
+
-channel gene,
GIRK1
, alone encodes I
KAch
-It is now shown that I
KAch
is a heteromultimer of two distinct inwardly rectifying K
+
-channel subunits, GIRK1 and a newly cloned member of the family, CIR.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>7877685</pmid><doi>10.1038/374135a0</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0028-0836 |
| ispartof | Nature (London), 1995-03, Vol.374 (6518), p.135-141 |
| issn | 0028-0836 1476-4687 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77163522 |
| source | MEDLINE; Nature Journals Online; SpringerLink Journals - AutoHoldings |
| subjects | Amino Acid Sequence Animals Biological and medical sciences Cell Line Cloning, Molecular Dogs Fundamental and applied biological sciences. Psychology G Protein-Coupled Inwardly-Rectifying Potassium Channels GTP-Binding Proteins - metabolism Heart Humanities and Social Sciences Ion Channel Gating Membrane Potentials Molecular Sequence Data multidisciplinary Myocardium - metabolism Oocytes Potassium Channels - chemistry Potassium Channels - genetics Potassium Channels - metabolism Potassium Channels, Inwardly Rectifying Protein Conformation Rats Recombinant Proteins Science Science (multidisciplinary) Vertebrates: cardiovascular system Xenopus |
| title | The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins |
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