The G-protein-gated atrial K+ channel IKAch is a heteromultimer of two inwardly rectifying K+-channel proteins

Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K + ) channel, I KACh . Activated muscarinic receptors stimulate l KAch via the G-protein βγ-subunits. It has been assumed that the inwardly rectifying K + -channel gene, GIRK1 , alone encodes I KAch -It is no...

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Veröffentlicht in:	Nature (London) 1995-03, Vol.374 (6518), p.135-141
Hauptverfasser:	Krapivinsky, G., Gordon, E. A., Wickman, K., Velimirović, B., Krapivinsky, L., Clapham, D. E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological and medical sciences Cell Line Cloning, Molecular Dogs Fundamental and applied biological sciences. Psychology G Protein-Coupled Inwardly-Rectifying Potassium Channels GTP-Binding Proteins - metabolism Heart Humanities and Social Sciences Ion Channel Gating Membrane Potentials Molecular Sequence Data multidisciplinary Myocardium - metabolism Oocytes Potassium Channels - chemistry Potassium Channels - genetics Potassium Channels - metabolism Potassium Channels, Inwardly Rectifying Protein Conformation Rats Recombinant Proteins Science Science (multidisciplinary) Vertebrates: cardiovascular system Xenopus
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Beschreibung
Zusammenfassung:	Heart rate is slowed in part by acetylcholine-dependent activation of a cardiac potassium (K + ) channel, I KACh . Activated muscarinic receptors stimulate l KAch via the G-protein βγ-subunits. It has been assumed that the inwardly rectifying K + -channel gene, GIRK1 , alone encodes I KAch -It is now shown that I KAch is a heteromultimer of two distinct inwardly rectifying K + -channel subunits, GIRK1 and a newly cloned member of the family, CIR.
ISSN:	0028-0836 1476-4687
DOI:	10.1038/374135a0