Inhibition of mitochondrial energy-linked reactions by 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (dimboa), a hydroxamic acid from gramineae
DIMBOA (2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one) is the main hydroxamic acid isolated from maize extracts. It inhibited reversibly ATP synthesis, P I-ATP exchange reaction and ATPase activity in submitochondrial particles from bovine heart. Half-maximal effects were obtained with 4, 2, and 6 mM...
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| Veröffentlicht in: | Biochemical pharmacology 1986-11, Vol.35 (22), p.3909-3914 |
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| container_title | Biochemical pharmacology |
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| creator | Niemeyer, Hermann M. Calcaterra, Nora B. Roveri, Oscar A. |
| description | DIMBOA (2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one) is the main hydroxamic acid isolated from maize extracts. It inhibited reversibly ATP synthesis, P
I-ATP exchange reaction and ATPase activity in submitochondrial particles from bovine heart. Half-maximal effects were obtained with 4, 2, and 6 mM DIMBOA respectively. At higher concentrations it also inhibited mitochondrial electron transport (
I
50 = 11 mM). Irreversible inactivation of mitochondrial electron transport, P
i-ATP exchange reaction and 8-anilino-1-naphthalene sulfonate energy-dependent fluorescence enhancement was also observed. These effects of DIMBOA on energy-linked mitochondrial reactions may explain the inhibitory action of DIMBOA on several aerobic organisms. |
| doi_str_mv | 10.1016/0006-2952(86)90003-1 |
| format | Article |
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I-ATP exchange reaction and ATPase activity in submitochondrial particles from bovine heart. Half-maximal effects were obtained with 4, 2, and 6 mM DIMBOA respectively. At higher concentrations it also inhibited mitochondrial electron transport (
I
50 = 11 mM). Irreversible inactivation of mitochondrial electron transport, P
i-ATP exchange reaction and 8-anilino-1-naphthalene sulfonate energy-dependent fluorescence enhancement was also observed. These effects of DIMBOA on energy-linked mitochondrial reactions may explain the inhibitory action of DIMBOA on several aerobic organisms.</description><identifier>ISSN: 0006-2952</identifier><identifier>EISSN: 1873-2968</identifier><identifier>DOI: 10.1016/0006-2952(86)90003-1</identifier><identifier>PMID: 2946299</identifier><identifier>CODEN: BCPCA6</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adenosine Triphosphatases - antagonists & inhibitors ; Adenosine Triphosphate - metabolism ; Animals ; Applied sciences ; Benzoxazines ; Biological and medical sciences ; Cattle ; Electron Transport - drug effects ; Energy Metabolism - drug effects ; Exact sciences and technology ; General and cellular metabolism. Vitamins ; Medical sciences ; Other techniques and industries ; Oxazines - pharmacology ; Pharmacology. Drug treatments ; Submitochondrial Particles - drug effects ; Submitochondrial Particles - metabolism ; Zea mays - analysis</subject><ispartof>Biochemical pharmacology, 1986-11, Vol.35 (22), p.3909-3914</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-8dae5437ef8a5340dce3c71dd4aadc982ddfcf7caeecc02f99cdbeeafe4cd1d3</citedby><cites>FETCH-LOGICAL-c415t-8dae5437ef8a5340dce3c71dd4aadc982ddfcf7caeecc02f99cdbeeafe4cd1d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-2952(86)90003-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8319849$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8349260$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2946299$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Niemeyer, Hermann M.</creatorcontrib><creatorcontrib>Calcaterra, Nora B.</creatorcontrib><creatorcontrib>Roveri, Oscar A.</creatorcontrib><title>Inhibition of mitochondrial energy-linked reactions by 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (dimboa), a hydroxamic acid from gramineae</title><title>Biochemical pharmacology</title><addtitle>Biochem Pharmacol</addtitle><description>DIMBOA (2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one) is the main hydroxamic acid isolated from maize extracts. It inhibited reversibly ATP synthesis, P
I-ATP exchange reaction and ATPase activity in submitochondrial particles from bovine heart. Half-maximal effects were obtained with 4, 2, and 6 mM DIMBOA respectively. At higher concentrations it also inhibited mitochondrial electron transport (
I
50 = 11 mM). Irreversible inactivation of mitochondrial electron transport, P
i-ATP exchange reaction and 8-anilino-1-naphthalene sulfonate energy-dependent fluorescence enhancement was also observed. These effects of DIMBOA on energy-linked mitochondrial reactions may explain the inhibitory action of DIMBOA on several aerobic organisms.</description><subject>Adenosine Triphosphatases - antagonists & inhibitors</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>Animals</subject><subject>Applied sciences</subject><subject>Benzoxazines</subject><subject>Biological and medical sciences</subject><subject>Cattle</subject><subject>Electron Transport - drug effects</subject><subject>Energy Metabolism - drug effects</subject><subject>Exact sciences and technology</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Medical sciences</subject><subject>Other techniques and industries</subject><subject>Oxazines - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Submitochondrial Particles - drug effects</subject><subject>Submitochondrial Particles - metabolism</subject><subject>Zea mays - analysis</subject><issn>0006-2952</issn><issn>1873-2968</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi0EKkvhDUDyAaFWqsFOnMS-IKGKP5UqcendcsbjriGxi52tmj4Ez0zCrvYIJ3u--c2n0TeEvBb8veCi_cA5b1mlm-pMted6qWomnpCNUF29yK16SjZH5Dl5UcqPtVStOCEnlZZtpfWG_L6K29CHKaRIk6djmBJsU3Q52IFixHw7syHEn-hoRgsrV2g_0-pCMhe2s8vpYWYdG3Harj-x6D3Gx_RgH0NkNUsR6ZkLY5_s-QW1dD9ixwDUQnDU5zTS27wIES2-JM-8HQq-Oryn5ObL55vLb-z6-9ery0_XDKRoJqacxUbWHXplm1pyB1hDJ5yT1jrQqnLOg-_AIgLwymsNrke0HiU44epT8m5ve5fTrx2WyYyhAA6DjZh2xXSdaHTT8AWUexByKiWjN3c5jDbPRnCzXsGsmZo1YqNa8_cKRixjbw7-u35Edxw6xL703x76toAdfLYRQjliqpa6avn_MaGVXN0-7jFcErsPmE2BgBHQhYwwGZfCv9f9A47Zs00</recordid><startdate>19861115</startdate><enddate>19861115</enddate><creator>Niemeyer, Hermann M.</creator><creator>Calcaterra, Nora B.</creator><creator>Roveri, Oscar A.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861115</creationdate><title>Inhibition of mitochondrial energy-linked reactions by 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (dimboa), a hydroxamic acid from gramineae</title><author>Niemeyer, Hermann M. ; Calcaterra, Nora B. ; Roveri, Oscar A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-8dae5437ef8a5340dce3c71dd4aadc982ddfcf7caeecc02f99cdbeeafe4cd1d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adenosine Triphosphatases - antagonists & inhibitors</topic><topic>Adenosine Triphosphate - metabolism</topic><topic>Animals</topic><topic>Applied sciences</topic><topic>Benzoxazines</topic><topic>Biological and medical sciences</topic><topic>Cattle</topic><topic>Electron Transport - drug effects</topic><topic>Energy Metabolism - drug effects</topic><topic>Exact sciences and technology</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Medical sciences</topic><topic>Other techniques and industries</topic><topic>Oxazines - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><topic>Submitochondrial Particles - drug effects</topic><topic>Submitochondrial Particles - metabolism</topic><topic>Zea mays - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Niemeyer, Hermann M.</creatorcontrib><creatorcontrib>Calcaterra, Nora B.</creatorcontrib><creatorcontrib>Roveri, Oscar A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Niemeyer, Hermann M.</au><au>Calcaterra, Nora B.</au><au>Roveri, Oscar A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of mitochondrial energy-linked reactions by 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (dimboa), a hydroxamic acid from gramineae</atitle><jtitle>Biochemical pharmacology</jtitle><addtitle>Biochem Pharmacol</addtitle><date>1986-11-15</date><risdate>1986</risdate><volume>35</volume><issue>22</issue><spage>3909</spage><epage>3914</epage><pages>3909-3914</pages><issn>0006-2952</issn><eissn>1873-2968</eissn><coden>BCPCA6</coden><abstract>DIMBOA (2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one) is the main hydroxamic acid isolated from maize extracts. It inhibited reversibly ATP synthesis, P
I-ATP exchange reaction and ATPase activity in submitochondrial particles from bovine heart. Half-maximal effects were obtained with 4, 2, and 6 mM DIMBOA respectively. At higher concentrations it also inhibited mitochondrial electron transport (
I
50 = 11 mM). Irreversible inactivation of mitochondrial electron transport, P
i-ATP exchange reaction and 8-anilino-1-naphthalene sulfonate energy-dependent fluorescence enhancement was also observed. These effects of DIMBOA on energy-linked mitochondrial reactions may explain the inhibitory action of DIMBOA on several aerobic organisms.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>2946299</pmid><doi>10.1016/0006-2952(86)90003-1</doi><tpages>6</tpages></addata></record> |
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| ispartof | Biochemical pharmacology, 1986-11, Vol.35 (22), p.3909-3914 |
| issn | 0006-2952 1873-2968 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adenosine Triphosphatases - antagonists & inhibitors Adenosine Triphosphate - metabolism Animals Applied sciences Benzoxazines Biological and medical sciences Cattle Electron Transport - drug effects Energy Metabolism - drug effects Exact sciences and technology General and cellular metabolism. Vitamins Medical sciences Other techniques and industries Oxazines - pharmacology Pharmacology. Drug treatments Submitochondrial Particles - drug effects Submitochondrial Particles - metabolism Zea mays - analysis |
| title | Inhibition of mitochondrial energy-linked reactions by 2,4-dihydroxy-7-methoxy-1,4-benzoxazin-3-one (dimboa), a hydroxamic acid from gramineae |
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