c-erbB-2/neu Oncogene and Ki-67 Analysis in the Assessment of Palatal Salivary Gland Neoplasms

To evaluate the role of the Ki-67 proliferation antigen and c-erbB-2/neu oncogene expression in the clinical assessment of salivary gland tumors, we followed up 71 patients with minor salivary tumors of the palate. All benign neoplasms (n= 18) showed low Ki-67 scores (< 12%), whereas 26% (14 of 5...

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Veröffentlicht in:	Otolaryngology-head and neck surgery 1995-03, Vol.112 (3), p.391-398
Hauptverfasser:	Giannoni, Carla, El-Naggar, Adel K., Ordonez, Nelson G., Nora Tu, Z., Austin, John, Luna, Mario A., Batsakis, John G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Carcinoma, Adenoid Cystic - genetics Carcinoma, Adenoid Cystic - metabolism Carcinoma, Adenoid Cystic - secondary Carcinoma, Adenoid Cystic - therapy Cohort Studies Female Follow-Up Studies Forecasting Gene Expression Regulation, Neoplastic Genes, erbB-2 - genetics Humans Ki-67 Antigen Male Middle Aged Multivariate Analysis Neoplasm Proteins - analysis Neoplasm Proteins - genetics Nuclear Proteins - analysis Nuclear Proteins - genetics Palatal Neoplasms - genetics Palatal Neoplasms - metabolism Palatal Neoplasms - therapy Salivary Gland Neoplasms - genetics Salivary Gland Neoplasms - metabolism Salivary Gland Neoplasms - therapy Salivary Glands, Minor - metabolism Survival Rate Treatment Outcome
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Zusammenfassung:	To evaluate the role of the Ki-67 proliferation antigen and c-erbB-2/neu oncogene expression in the clinical assessment of salivary gland tumors, we followed up 71 patients with minor salivary tumors of the palate. All benign neoplasms (n= 18) showed low Ki-67 scores (< 12%), whereas 26% (14 of 53) of malignant neoplasms manifested high Ki-67 scores (
ISSN:	0194-5998 1097-6817
DOI:	10.1016/S0194-59989570272-5