Croblongifolin, a New Anticancer Clerodane from Croton oblongifolius

Abstract A new furoclerodane, croblongifolin, together with one known clerodane, crovatin and one known labdane, nidorellol, were isolated from the stem bark of CROTON OBLONGIFOLIUS. Structures were established based on spectroscopic and X-ray analysis. Croblongifolin showed a significant cytotoxici...

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Veröffentlicht in:	Planta medica 2002-03, Vol.68 (3), p.274-277
Hauptverfasser:	Roengsumran, Sophon, Musikul, Kusalin, Petsom, Amorn, Vilaivan, Tirayut, Sangvanich, Polkit, Pornpakakul, Surachai, Puthong, Songchan, Chaichantipyuth, Chaiyo, Jaiboon, Nongnuj, Chaichit, Narongsak
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacology Biological and medical sciences Croton Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Diterpenes, Clerodane Doxorubicin - pharmacology Furans - chemistry Furans - isolation & purification Furans - pharmacology General pharmacology Humans Letter Magnetic Resonance Spectroscopy Medical sciences Molecular Structure Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plant Bark - chemistry Plant Extracts - pharmacology Tumor Cells, Cultured - drug effects X-Ray Diffraction
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Zusammenfassung:	Abstract A new furoclerodane, croblongifolin, together with one known clerodane, crovatin and one known labdane, nidorellol, were isolated from the stem bark of CROTON OBLONGIFOLIUS. Structures were established based on spectroscopic and X-ray analysis. Croblongifolin showed a significant cytotoxicity against various human tumor cell lines including HEP-G2, SW620, CHAGO, KATO3 and BT474.
ISSN:	0032-0943 1439-0221
DOI:	10.1055/s-2002-23138