Polymorphism of the murine inhibitor of differentiation-controlling gene, Id

The structure of Id was examined by Southern analysis in inbred mouse lines which included five subspecies of Mus musculus. No variation was detected within this species. The species Mus cookii shares the same form found in mice of M. musculus derivation, indicative of a long evolutionary history an...

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Veröffentlicht in:	Gene 1995-02, Vol.153 (2), p.281-282
Hauptverfasser:	Marlow, S.A., Kay, P.H., Papadimitriou, J.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Deoxyribonucleases, Type II Site-Specific DNA-Binding Proteins - genetics genetics helix-loop-helix Helix-Loop-Helix Motifs - genetics Inhibitor of Differentiation Protein 1 Mice Mice, Inbred Strains - genetics Muridae - genetics Mus musculus Polymorphism, Restriction Fragment Length Repressor Proteins Southern blotting Transcription Factors
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Zusammenfassung:	The structure of Id was examined by Southern analysis in inbred mouse lines which included five subspecies of Mus musculus. No variation was detected within this species. The species Mus cookii shares the same form found in mice of M. musculus derivation, indicative of a long evolutionary history and a common origin. However, five TaqI polymorphisms were found among several Mus species, suggesting that Id has been modified throughout species diversification. Whether these variants impart functional changes is yet to be determined.
ISSN:	0378-1119 1879-0038
DOI:	10.1016/0378-1119(94)00766-L