Cardiorespiratory inhibitory reflex induced by intravenous administration of acetaldehyde in rats

In urethane anesthetized rats, intravenous administration of a bolus of acetaldehyde (diluted 50 times its volume in Ringer Locke solution) induced after a latency of about 1 second, a triple reflex response characterized by transient bradycardia, hypotension and apnea. Intensity of both bradycardia...

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Veröffentlicht in:	Alcohol (Fayetteville, N.Y.) N.Y.), 1986-09, Vol.3 (5), p.317-322
Hauptverfasser:	Brugere, Solange, Saavedra, Alvaro, Penna, Mario
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaldehyde Acetaldehyde - pharmacology Alcoholism and acute alcohol poisoning Animals Apnea Biological and medical sciences Blood Pressure - drug effects Bradycardia Cardiorespiratory reflex Female Heart Rate - drug effects Hypotension Male Medical sciences Rats Reflex - drug effects Respiration - drug effects Toxicology Vagotomy
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Zusammenfassung:	In urethane anesthetized rats, intravenous administration of a bolus of acetaldehyde (diluted 50 times its volume in Ringer Locke solution) induced after a latency of about 1 second, a triple reflex response characterized by transient bradycardia, hypotension and apnea. Intensity of both bradycardia (r=−0.78) and hypotension (r=−0.74) were dose dependent ( p
ISSN:	0741-8329 1873-6823
DOI:	10.1016/0741-8329(86)90008-X