New Phenylpropanoid Esters of Sucrose from Polygonum lapathifolium

Four new phenylpropanoid esters of sucrose, lapathosides A (1), B (2), C (3), and D (4), were isolated from the aerial parts of Polygonum lapathifolium together with known esters, vanicoside B (5) and hydropiperoside (6). The structures of 1−4 were determined by spectral (1D and 2D NMR and MS) analy...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2001-10, Vol.64 (10), p.1305-1308
Hauptverfasser:	Takasaki, Midori, Kuroki, Satoshi, Kozuka, Mutsuo, Konoshima, Takao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticarcinogenic Agents - pharmacology Antigens, Viral - drug effects Antigens, Viral - physiology Biological and medical sciences Cinnamates - chemistry Cinnamates - isolation & purification Cinnamates - pharmacology Disaccharides - chemistry Disaccharides - isolation & purification Disaccharides - pharmacology Dose-Response Relationship, Drug Epstein-Barr virus Epstein-Barr Virus Nuclear Antigens - drug effects Epstein-Barr Virus Nuclear Antigens - physiology Esters - chemistry General pharmacology Humans lapathoside A Lymphoma, B-Cell Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Medicine, Chinese Traditional Nitric Oxide Donors - pharmacology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Plants, Medicinal - chemistry Polygonum - chemistry Polygonum lapathifolium Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Sucrose - analogs & derivatives Sucrose - chemistry Tumor Cells, Cultured - drug effects vanicoside B Virus Activation - drug effects
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Zusammenfassung:	Four new phenylpropanoid esters of sucrose, lapathosides A (1), B (2), C (3), and D (4), were isolated from the aerial parts of Polygonum lapathifolium together with known esters, vanicoside B (5) and hydropiperoside (6). The structures of 1−4 were determined by spectral (1D and 2D NMR and MS) analysis. Lapathoside A (1) and vanicoside B (2) showed significant inhibitory effects on the Epstein−Barr virus early antigen activation by tumor-promoters.
ISSN:	0163-3864 1520-6025
DOI:	10.1021/np010222q