Darlucins A and B, New Isocyanide Antibiotics from Sphaerellopsis filum (Darluca filum)
Two new xanthocillin type antibiotics, darlucin A (1) and B (2), were isolated from fermentations of Sphaerellopsis filum (Darluca filum). Their structures were established by spectroscopic methods. The darlucins are the first known compounds with a 1, 2-diisocyanoalkene moiety. Both compounds exhib...
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| Veröffentlicht in: | Journal of antibiotics 1995/01/25, Vol.48(1), pp.36-41 |
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| container_end_page | 41 |
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| container_issue | 1 |
| container_start_page | 36 |
| container_title | Journal of antibiotics |
| container_volume | 48 |
| creator | ZAPF, SYLVIA HOßFELD, MARTIN ANKE, HEIDRUN VELTEN, ROBERT STEGLICH, WOLFGANG |
| description | Two new xanthocillin type antibiotics, darlucin A (1) and B (2), were isolated from fermentations of Sphaerellopsis filum (Darluca filum). Their structures were established by spectroscopic methods. The darlucins are the first known compounds with a 1, 2-diisocyanoalkene moiety. Both compounds exhibited antibacterial, antifungal and weak cytotoxic activities. |
| doi_str_mv | 10.7164/antibiotics.48.36 |
| format | Article |
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Their structures were established by spectroscopic methods. The darlucins are the first known compounds with a 1, 2-diisocyanoalkene moiety. Both compounds exhibited antibacterial, antifungal and weak cytotoxic activities.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.48.36</identifier><identifier>PMID: 7868387</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Animals ; Anti-Bacterial Agents - biosynthesis ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Biological and medical sciences ; Cell Division - drug effects ; Cells, Cultured ; Cyanides - isolation & purification ; Cyanides - metabolism ; Cyanides - pharmacology ; Cyclohexanones - isolation & purification ; Cyclohexanones - metabolism ; Cyclohexanones - pharmacology ; Fermentation ; Fungi - drug effects ; Gram-Negative Bacteria - drug effects ; Gram-Positive Bacteria - drug effects ; HeLa Cells ; Humans ; Hydroquinones - isolation & purification ; Hydroquinones - metabolism ; Hydroquinones - pharmacology ; Magnetic Resonance Spectroscopy ; Medical sciences ; Mice ; Microbial Sensitivity Tests ; Miscellaneous. Antibiotics with multiple activities ; Mitosporic Fungi - chemistry ; Mitosporic Fungi - metabolism ; Pharmacology. Drug treatments ; Spectrophotometry, Infrared ; Sphaerellopsis filum</subject><ispartof>The Journal of Antibiotics, 1995/01/25, Vol.48(1), pp.36-41</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6136-3d8597ee0403efb8b640427adba8bbd6474a5d76d293a132a23d1e899979704f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3464586$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7868387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ZAPF, SYLVIA</creatorcontrib><creatorcontrib>HOßFELD, MARTIN</creatorcontrib><creatorcontrib>ANKE, HEIDRUN</creatorcontrib><creatorcontrib>VELTEN, ROBERT</creatorcontrib><creatorcontrib>STEGLICH, WOLFGANG</creatorcontrib><title>Darlucins A and B, New Isocyanide Antibiotics from Sphaerellopsis filum (Darluca filum)</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>Two new xanthocillin type antibiotics, darlucin A (1) and B (2), were isolated from fermentations of Sphaerellopsis filum (Darluca filum). Their structures were established by spectroscopic methods. The darlucins are the first known compounds with a 1, 2-diisocyanoalkene moiety. Both compounds exhibited antibacterial, antifungal and weak cytotoxic activities.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - biosynthesis</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Cells, Cultured</subject><subject>Cyanides - isolation & purification</subject><subject>Cyanides - metabolism</subject><subject>Cyanides - pharmacology</subject><subject>Cyclohexanones - isolation & purification</subject><subject>Cyclohexanones - metabolism</subject><subject>Cyclohexanones - pharmacology</subject><subject>Fermentation</subject><subject>Fungi - drug effects</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>Gram-Positive Bacteria - drug effects</subject><subject>HeLa Cells</subject><subject>Humans</subject><subject>Hydroquinones - isolation & purification</subject><subject>Hydroquinones - metabolism</subject><subject>Hydroquinones - pharmacology</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Miscellaneous. Antibiotics with multiple activities</subject><subject>Mitosporic Fungi - chemistry</subject><subject>Mitosporic Fungi - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Spectrophotometry, Infrared</subject><subject>Sphaerellopsis filum</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtP3DAUha2KCgbaH8ACyQuEQGqmduzYN8spLS-hdtFWXVo3tgNGeQz2RNX8ezLKaGDHxpbv-e451iHkmLO55kp-xW4VqtCvgk1zCXOhPpAZB-AZl6rcIzPGcp4B5OyAHKb0xJjQQsM-2degQICekX_fMTaDDV2iC4qdo9--0J_-P71NvV1jF5yni9cQWse-pb-Xj-ijb5p-mcI4C83Q0vPJCKfnxSfyscYm-c_b-4j8vfrx5_Imu_91fXu5uM-s4kJlwkFRau-ZZMLXFVRKMplrdBVCVTkltcTCaeXyUiAXOebCcQ9lWepSM1mLI3I2-S5j_zz4tDJtSHb8G3a-H5LRmhdcFPAuyJUeMS1HkE-gjX1K0ddmGUOLcW04M5vWzZvWjQQj1LhzsjUfqta73ca25lE_3eqYLDZ1xM6GtMOEVLKAjc3dhD2lFT74nY5xzGr822BeKtiE8-kQagfZR4zGd-IFnH-njA</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>ZAPF, SYLVIA</creator><creator>HOßFELD, MARTIN</creator><creator>ANKE, HEIDRUN</creator><creator>VELTEN, ROBERT</creator><creator>STEGLICH, WOLFGANG</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Darlucins A and B, New Isocyanide Antibiotics from Sphaerellopsis filum (Darluca filum)</title><author>ZAPF, SYLVIA ; HOßFELD, MARTIN ; ANKE, HEIDRUN ; VELTEN, ROBERT ; STEGLICH, WOLFGANG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6136-3d8597ee0403efb8b640427adba8bbd6474a5d76d293a132a23d1e899979704f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - biosynthesis</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Biological and medical sciences</topic><topic>Cell Division - drug effects</topic><topic>Cells, Cultured</topic><topic>Cyanides - isolation & purification</topic><topic>Cyanides - metabolism</topic><topic>Cyanides - pharmacology</topic><topic>Cyclohexanones - isolation & purification</topic><topic>Cyclohexanones - metabolism</topic><topic>Cyclohexanones - pharmacology</topic><topic>Fermentation</topic><topic>Fungi - drug effects</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>Gram-Positive Bacteria - drug effects</topic><topic>HeLa Cells</topic><topic>Humans</topic><topic>Hydroquinones - isolation & purification</topic><topic>Hydroquinones - metabolism</topic><topic>Hydroquinones - pharmacology</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Miscellaneous. Antibiotics with multiple activities</topic><topic>Mitosporic Fungi - chemistry</topic><topic>Mitosporic Fungi - metabolism</topic><topic>Pharmacology. 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Antibiot.</addtitle><date>1995</date><risdate>1995</risdate><volume>48</volume><issue>1</issue><spage>36</spage><epage>41</epage><pages>36-41</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>Two new xanthocillin type antibiotics, darlucin A (1) and B (2), were isolated from fermentations of Sphaerellopsis filum (Darluca filum). Their structures were established by spectroscopic methods. The darlucins are the first known compounds with a 1, 2-diisocyanoalkene moiety. Both compounds exhibited antibacterial, antifungal and weak cytotoxic activities.</abstract><cop>Tokyo</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>7868387</pmid><doi>10.7164/antibiotics.48.36</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1995/01/25, Vol.48(1), pp.36-41 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77151358 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Animals Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cell Division - drug effects Cells, Cultured Cyanides - isolation & purification Cyanides - metabolism Cyanides - pharmacology Cyclohexanones - isolation & purification Cyclohexanones - metabolism Cyclohexanones - pharmacology Fermentation Fungi - drug effects Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects HeLa Cells Humans Hydroquinones - isolation & purification Hydroquinones - metabolism Hydroquinones - pharmacology Magnetic Resonance Spectroscopy Medical sciences Mice Microbial Sensitivity Tests Miscellaneous. Antibiotics with multiple activities Mitosporic Fungi - chemistry Mitosporic Fungi - metabolism Pharmacology. Drug treatments Spectrophotometry, Infrared Sphaerellopsis filum |
| title | Darlucins A and B, New Isocyanide Antibiotics from Sphaerellopsis filum (Darluca filum) |
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