Darlucins A and B, New Isocyanide Antibiotics from Sphaerellopsis filum (Darluca filum)

Two new xanthocillin type antibiotics, darlucin A (1) and B (2), were isolated from fermentations of Sphaerellopsis filum (Darluca filum). Their structures were established by spectroscopic methods. The darlucins are the first known compounds with a 1, 2-diisocyanoalkene moiety. Both compounds exhib...

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Veröffentlicht in:	Journal of antibiotics 1995/01/25, Vol.48(1), pp.36-41
Hauptverfasser:	ZAPF, SYLVIA, HOßFELD, MARTIN, ANKE, HEIDRUN, VELTEN, ROBERT, STEGLICH, WOLFGANG
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Biological and medical sciences Cell Division - drug effects Cells, Cultured Cyanides - isolation & purification Cyanides - metabolism Cyanides - pharmacology Cyclohexanones - isolation & purification Cyclohexanones - metabolism Cyclohexanones - pharmacology Fermentation Fungi - drug effects Gram-Negative Bacteria - drug effects Gram-Positive Bacteria - drug effects HeLa Cells Humans Hydroquinones - isolation & purification Hydroquinones - metabolism Hydroquinones - pharmacology Magnetic Resonance Spectroscopy Medical sciences Mice Microbial Sensitivity Tests Miscellaneous. Antibiotics with multiple activities Mitosporic Fungi - chemistry Mitosporic Fungi - metabolism Pharmacology. Drug treatments Spectrophotometry, Infrared Sphaerellopsis filum
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Zusammenfassung:	Two new xanthocillin type antibiotics, darlucin A (1) and B (2), were isolated from fermentations of Sphaerellopsis filum (Darluca filum). Their structures were established by spectroscopic methods. The darlucins are the first known compounds with a 1, 2-diisocyanoalkene moiety. Both compounds exhibited antibacterial, antifungal and weak cytotoxic activities.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.48.36