Structural determination of a new naturally occurring cyclic vitamin K

The respiratory quinone composition of 5 members of the genus Nocardia was examined. All species contained a hitherto unknown cyclic vitamin K-like molecule as their predominant lipoquinone. On the basis of mass spectrometry, 1H and 13C nuclear magnetic resonance spectrometry, the novel quinone was...

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Veröffentlicht in:Biochemical and biophysical research communications 1986-11, Vol.140 (3), p.916-923
Hauptverfasser: Howarth, O.W., Grund, E., Kroppenstedt, R.M., Collins, M.D.
Format: Artikel
Sprache:eng
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Zusammenfassung:The respiratory quinone composition of 5 members of the genus Nocardia was examined. All species contained a hitherto unknown cyclic vitamin K-like molecule as their predominant lipoquinone. On the basis of mass spectrometry, 1H and 13C nuclear magnetic resonance spectrometry, the novel quinone was shown to correspond to (2 E,14 E,18 E,22 E)-2-[3,7,11,15,19, 23-hexamethyl-25-(2,6,6-trimethylcyclohex-2-enyl)pentacosa-2,14,18,22-tetraenyl]-3-methyl-1,4-naphthoquinone. Results indicate this molecule may respresent a valuable phylogenetic marker for the prokaryote genus Nocardia.
ISSN:0006-291X
1090-2104
DOI:10.1016/0006-291X(86)90722-9