Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L
A squamous cell carcinoma antigen (SSCA), which is a member of the serpin family of proteinase inhibitors, was purified from sera of cancer patients. It did not inhibit serine proteinases. However, it non-competitively inhibited human cathepsin L with a K i of 0.064 nM, but not cathepsins B and H am...
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| Veröffentlicht in: | FEBS letters 1995-02, Vol.359 (1), p.78-80 |
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| creator | Takeda, Atsushi Yamamoto, Takako Nakamura, Yoshiko Takahashi, Tadahito Hibino, Toshihiko |
| description | A squamous cell carcinoma antigen (SSCA), which is a member of the serpin family of proteinase inhibitors, was purified from sera of cancer patients. It did not inhibit serine proteinases. However, it non-competitively inhibited human cathepsin L with a
K
i of 0.064 nM, but not cathepsins B and H among cysteine proteinases. These results indicated that SCCA is a non-functional serpin that inhibits cathepsin L in cancer cells. |
| doi_str_mv | 10.1016/0014-5793(94)01456-B |
| format | Article |
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K
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K
i of 0.064 nM, but not cathepsins B and H among cysteine proteinases. These results indicated that SCCA is a non-functional serpin that inhibits cathepsin L in cancer cells.</description><subject>Animals</subject><subject>Antigens, Neoplasm - blood</subject><subject>Antigens, Neoplasm - pharmacology</subject><subject>Boc, t-butyloxycarbonyl</subject><subject>Carcinoma, Squamous Cell - immunology</subject><subject>Cathepsin L</subject><subject>Cathepsins - antagonists & inhibitors</subject><subject>Chromatography, Affinity</subject><subject>Cysteine Endopeptidases</subject><subject>DTT, dithiothreitol</subject><subject>Endopeptidases</subject><subject>Female</subject><subject>FPLC, fast protein liquid chromatography</subject><subject>HPLC, high performance liquid chromatography</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Lung Neoplasms - immunology</subject><subject>MCA, 4-methylcoumaryl-7-amide</subject><subject>Protease Inhibitors - pharmacology</subject><subject>Proteinase inhibitor</subject><subject>SCCA, squamous cell carcinoma antigen</subject><subject>SDS, sodium dodecyl sulfate</subject><subject>Serpin</subject><subject>Serpins</subject><subject>Squamous cell carcinoma antigen (SCCA)</subject><subject>Suc(OMe), N-methoxysuccinyl</subject><subject>Suc, succinyl</subject><subject>Swine</subject><subject>Uterine Cervical Neoplasms - immunology</subject><subject>Z, carbobenzoxy</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUEtLAzEQDqLU-vgHCjmJHlaTTbbZXAQrVoWCBxW8hWwyayPdbE22Sv-92bZ4FE-Zme-RmQ-hE0ouKaGjK0Iozwoh2bnkF6kuRtl4Bw1pKVjG-KjcRcNfyj46iPGDpL6kcoAGoixowYohenv-XOqmXUZsYD7HRgfjfNtorH3n3sFjF7HGi7YD32HnZ65yXRtwW2Ozih04D3gR2r7QEZK8m8EiOo-nR2iv1vMIx9v3EL1O7l5uH7Lp0_3j7c00MwXLxxkQmWsNVuY1rQi1dWVrA7lkzBqWy6LiYlSa1JBKEFnaSlueeFJWUgphKTtEZxvftMbnEmKnGhf7W7SHdJYSgnIuZJmIfEM0oY0xQK0WwTU6rBQlqg9U9WmpPi0luVoHqsZJdrr1X1YN2F_RNsGETzb4t5vD6l-eanI3znugn0u-nvYfXW-MIKX15SCoaBx4A9YFMJ2yrft70x-eS5l0</recordid><startdate>19950206</startdate><enddate>19950206</enddate><creator>Takeda, Atsushi</creator><creator>Yamamoto, Takako</creator><creator>Nakamura, Yoshiko</creator><creator>Takahashi, Tadahito</creator><creator>Hibino, Toshihiko</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950206</creationdate><title>Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L</title><author>Takeda, Atsushi ; Yamamoto, Takako ; Nakamura, Yoshiko ; Takahashi, Tadahito ; Hibino, Toshihiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c532B-e092aaed92f1b01dfbdfce2933dc3295b4768c3dc0b7098dbad4b0199b9977d13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Antigens, Neoplasm - blood</topic><topic>Antigens, Neoplasm - pharmacology</topic><topic>Boc, t-butyloxycarbonyl</topic><topic>Carcinoma, Squamous Cell - immunology</topic><topic>Cathepsin L</topic><topic>Cathepsins - antagonists & inhibitors</topic><topic>Chromatography, Affinity</topic><topic>Cysteine Endopeptidases</topic><topic>DTT, dithiothreitol</topic><topic>Endopeptidases</topic><topic>Female</topic><topic>FPLC, fast protein liquid chromatography</topic><topic>HPLC, high performance liquid chromatography</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Lung Neoplasms - immunology</topic><topic>MCA, 4-methylcoumaryl-7-amide</topic><topic>Protease Inhibitors - pharmacology</topic><topic>Proteinase inhibitor</topic><topic>SCCA, squamous cell carcinoma antigen</topic><topic>SDS, sodium dodecyl sulfate</topic><topic>Serpin</topic><topic>Serpins</topic><topic>Squamous cell carcinoma antigen (SCCA)</topic><topic>Suc(OMe), N-methoxysuccinyl</topic><topic>Suc, succinyl</topic><topic>Swine</topic><topic>Uterine Cervical Neoplasms - immunology</topic><topic>Z, carbobenzoxy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takeda, Atsushi</creatorcontrib><creatorcontrib>Yamamoto, Takako</creatorcontrib><creatorcontrib>Nakamura, Yoshiko</creatorcontrib><creatorcontrib>Takahashi, Tadahito</creatorcontrib><creatorcontrib>Hibino, Toshihiko</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takeda, Atsushi</au><au>Yamamoto, Takako</au><au>Nakamura, Yoshiko</au><au>Takahashi, Tadahito</au><au>Hibino, Toshihiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1995-02-06</date><risdate>1995</risdate><volume>359</volume><issue>1</issue><spage>78</spage><epage>80</epage><pages>78-80</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>A squamous cell carcinoma antigen (SSCA), which is a member of the serpin family of proteinase inhibitors, was purified from sera of cancer patients. It did not inhibit serine proteinases. However, it non-competitively inhibited human cathepsin L with a
K
i of 0.064 nM, but not cathepsins B and H among cysteine proteinases. These results indicated that SCCA is a non-functional serpin that inhibits cathepsin L in cancer cells.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>7851535</pmid><doi>10.1016/0014-5793(94)01456-B</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | FEBS letters, 1995-02, Vol.359 (1), p.78-80 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Antigens, Neoplasm - blood Antigens, Neoplasm - pharmacology Boc, t-butyloxycarbonyl Carcinoma, Squamous Cell - immunology Cathepsin L Cathepsins - antagonists & inhibitors Chromatography, Affinity Cysteine Endopeptidases DTT, dithiothreitol Endopeptidases Female FPLC, fast protein liquid chromatography HPLC, high performance liquid chromatography Humans Kinetics Lung Neoplasms - immunology MCA, 4-methylcoumaryl-7-amide Protease Inhibitors - pharmacology Proteinase inhibitor SCCA, squamous cell carcinoma antigen SDS, sodium dodecyl sulfate Serpin Serpins Squamous cell carcinoma antigen (SCCA) Suc(OMe), N-methoxysuccinyl Suc, succinyl Swine Uterine Cervical Neoplasms - immunology Z, carbobenzoxy |
| title | Squamous cell carcinoma antigen is a potent inhibitor of cysteine proteinase cathepsin L |
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