Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

The radiosensitive rodent mutant cell line xrs-5 is defective in DNA double-strand break repair and lacks the Ku component of the DNA-activated protein kinase, DNA-PK. Here radiosensitive human cell lines were analyzed for DNA-PK activity and for the presence of related proteins. The radiosensitive...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science 1995-02, Vol.267 (5201), p.1183-1185
Hauptverfasser:	Lees-Miller, Susan P., Godbout, Roseline, Chan, Doug W., Weinfeld, Michael, Day, Rufus S., Barron, Geraldine M., Allalunis-Turner, Joan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antigens, Nuclear Biochemistry Biological and medical sciences BIOLOGICAL REPAIR BIOLOGY AND MEDICINE, APPLIED STUDIES Cell extracts Cell Line, Transformed Cell lines CHO Cells Cricetinae Deoxyribonucleic acid DNA DNA - metabolism DNA Helicases DNA Repair DNA-Activated Protein Kinase DNA-Binding Proteins - analysis ECOLOGICAL CONCENTRATION Fundamental and applied biological sciences. Psychology Gamma Rays Gels Genes GENETIC RADIATION EFFECTS Glioma HeLa cells HUMAN POPULATIONS Humans Ionizing radiation Ku Autoantigen MAN Molecular and cellular biology Molecular genetics Molecular Sequence Data Mutagenesis. Repair Mutation Nuclear Proteins - analysis p350 subunit PHOSPHOTRANSFERASES protein kinase Protein kinases Protein-Serine-Threonine Kinases - metabolism Radiation Tolerance RNA Rodents Transcripts (Written Records) Tumor Cells, Cultured X RADIATION
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!