Excitatory action of BAYK8644 on hippocampal pyramidal neurones of the guinea pig in vitro

BAYK8644, a calcium ‘agonist’ caused a slow depolarization of a proportion of CA 1 hippocampal pyramidal cells and increased their input resistance. In voltage-clamped CA 1 neurones BAYK8644 caused a decrease in depolarization-activated outward current. Reduction of depolarization-activated outward...

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Veröffentlicht in:	Neuroscience letters 1986-10, Vol.70 (2), p.239-244
Hauptverfasser:	Docherty, R.J., Brown, D.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	1,4-Dihydropyridine 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology Action Potentials - drug effects Animals BAYK8644 Biological and medical sciences Calcimycin - pharmacology Calcium - physiology Guinea Pigs Hippocampus Hippocampus - drug effects In Vitro Techniques Ion Channels - drug effects Medical sciences Membrane Potentials - drug effects Miscellaneous Neurons - drug effects Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Nimodipine - pharmacology Pharmacology. Drug treatments Potassium - physiology Voltage clamp
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Zusammenfassung:	BAYK8644, a calcium ‘agonist’ caused a slow depolarization of a proportion of CA 1 hippocampal pyramidal cells and increased their input resistance. In voltage-clamped CA 1 neurones BAYK8644 caused a decrease in depolarization-activated outward current. Reduction of depolarization-activated outward current was also produced by the Ca ionophore A23187. It is proposed that BAYK8644 and A23187 may cause suppression of outward current secondary to a prolonged increase in cytosolic Ca activity.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(86)90470-2