Spurious fibrinogen levels secondary to pyroglobulinemia in Waldenström's macroglobulinemia

We report two cases of pyroglobulinemia detected in the course of routine determination of fibrinogen levels measured by the heat‐precipitation method and that led to the diagnosis of Waldenström's macroglobulinemia. The Incidence of pyroglobulinemia is briefly discussed, and the potential sign...

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Veröffentlicht in:	American journal of hematology 1995-02, Vol.48 (2), p.126-127
Hauptverfasser:	Cagnoni, Pablo J., Lenzi, Renato, Wisch, Nathaniel, Seremetis, Stephanie, Rand, Jacob H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal Biological and medical sciences Bone Marrow - pathology Chemical Precipitation Female fibrinogen Fibrinogen - metabolism Hot Temperature Humans Immunodeficiencies. Immunoglobulinopathies Immunoelectrophoresis Immunoglobulin lambda-Chains - blood Immunoglobulin lambda-Chains - urine Immunoglobulin M - blood Immunoglobulinopathies Immunopathology Medical sciences Middle Aged pyroglobulin Pyroglobulins - metabolism Waldenstrom Macroglobulinemia - blood Waldenstrom Macroglobulinemia - diagnosis Waldenstrom's macroglobulinemia
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Zusammenfassung:	We report two cases of pyroglobulinemia detected in the course of routine determination of fibrinogen levels measured by the heat‐precipitation method and that led to the diagnosis of Waldenström's macroglobulinemia. The Incidence of pyroglobulinemia is briefly discussed, and the potential significance of this laboratory artifact is emphasized.
ISSN:	0361-8609 1096-8652
DOI:	10.1002/ajh.2830480212