Calcitonin gene-related peptide regulates muscle acetylcholine receptor synthesis

Innervation of muscle by motoneurones induces the development of a characteristic, high density cluster of acetylcholine receptors (AChRs) at the neuromuscular junction 1–4 . Studies in vitro show that the accumulation of AChRs at nerve–muscle contacts results from both increased insertion of new AC...

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Veröffentlicht in:Nature (London) 1986-10, Vol.323 (6091), p.809-811
Hauptverfasser: New, Helen V., Mudge, Anne W.
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Sprache:eng
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Zusammenfassung:Innervation of muscle by motoneurones induces the development of a characteristic, high density cluster of acetylcholine receptors (AChRs) at the neuromuscular junction 1–4 . Studies in vitro show that the accumulation of AChRs at nerve–muscle contacts results from both increased insertion of new AChRs into the muscle plasma membrane beneath nerve terminals 5 and redistribution of preexisting AChRs 5–7 ; these two modes of AChR accumulation may be separately controlled since factors have been identified that influence AChR redistribution but not synthesis 8,9 . Although many aspects of muscle development are regulated by nerve-dependent muscle activity 10–16 , junctional AChR clusters still develop when neuromuscular transmission is blocked by either curare or α -bungarotoxin 1,5,6,17 , suggesting that their formation is mediated by nerve-derived trophic factors other than activity. A molecule immunologically related to calcitonin gene-related peptide (CGRP-I) has been found in motoneurones in a variety of mammals including man 18,19 . Here we provide indirect evidence that CGRP-I may be a motoneurone-derived trophic factor that increases AChR synthesis at vertebrate neuromuscular junctions.
ISSN:0028-0836
1476-4687
DOI:10.1038/323809a0