Atriopeptin III does not Alter Cardiac Performance in Rats

The effects of atriopeptin III (API 11) on systemic haemodynamics were examined in 12 anaesthetized rats. Five minutes following intravenous injection (i.v.) of 10 n-g/kg APIII, cardiac output CO, measured by electromagnetic flowmetry, stroke volume and mean arterial pressure (MAP) decreased by 14,...

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Veröffentlicht in:	Journal of hypertension 1986-08, Vol.4 (4), p.477-480
Hauptverfasser:	Natsume, Takashi, Kardon, Merril B, Trippodo, Nick C, Januszewicz, Andrzej, Pegram, Barbara L, Frohlich, Edward D
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atrial Natriuretic Factor - pharmacology Biological and medical sciences Blood Pressure - drug effects Cardiac Output - drug effects Fundamental and applied biological sciences. Psychology Heart Rate - drug effects Hemodynamics - drug effects Hemodynamics. Rheology In Vitro Techniques Male Rats Rats, Inbred Strains Stroke Volume - drug effects Vascular Resistance - drug effects Vertebrates: cardiovascular system
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Zusammenfassung:	The effects of atriopeptin III (API 11) on systemic haemodynamics were examined in 12 anaesthetized rats. Five minutes following intravenous injection (i.v.) of 10 n-g/kg APIII, cardiac output CO, measured by electromagnetic flowmetry, stroke volume and mean arterial pressure (MAP) decreased by 14, 13 and 8% (P
ISSN:	0263-6352 1473-5598
DOI:	10.1097/00004872-198608000-00013