Systolic and diastolic effects of beta-adrenergic stimulation in normal humans

Systolic and diastolic effects of beta-adrenergic stimulation in normal humans

We conclude that stimulation of β-adrenergic receptors with low-dose isoprenaline exerts greater effects on myocardial relaxation than contraction. This suggests that diastolic function is exquisitely sensitive to acute changes in sympathetic tone, a finding that may have relevance in the pathogenes...

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Veröffentlicht in:The American journal of cardiology 1995-01, Vol.75 (2), p.206-209
Hauptverfasser: Mark Clarkson, Peter Bruce, Wheeldon, Nigel Mark, Macleod, Catherine, MacDonald, Thomas MacLennan
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Blood Pressure - drug effects
Cardiovascular system
Drug therapy
Echocardiography, Doppler
Heart
Heart Rate - drug effects
Humans
Investigative techniques, diagnostic techniques (general aspects)
Isoproterenol - pharmacology
Male
Medical research
Medical sciences
Metabolism
Myocardial Contraction - drug effects
Receptors, Adrenergic, beta - drug effects
Reference Values
Stimulation, Chemical
Ultrasonic investigative techniques
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Zusammenfassung:We conclude that stimulation of β-adrenergic receptors with low-dose isoprenaline exerts greater effects on myocardial relaxation than contraction. This suggests that diastolic function is exquisitely sensitive to acute changes in sympathetic tone, a finding that may have relevance in the pathogenesis and treatment of disease states associated with impaired ventricular filling.
ISSN:0002-9149
1879-1913
DOI:10.1016/S0002-9149(00)80084-3