In vitro selection of catalytic RNAs

In vitro selection techniques are poised to allow a rapid expansion of the study of catalysis by RNA enzymes (ribozymes). This truly molecular version of genetics has already been applied to the study of the structures of known ribozymes and to the tailoring of their catalytic activity to meet speci...

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Veröffentlicht in:	Current opinion in structural biology 1994, Vol.4 (4), p.618-622
Hauptverfasser:	Chapman, Karen B., Szostak, Jack W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalysis Endoribonucleases - chemistry Endoribonucleases - genetics Endoribonucleases - isolation & purification Endoribonucleases - metabolism Evolution, Molecular Exobiology Genetic Techniques Introns - genetics Ribonuclease P Ribonucleoproteins - chemistry Ribonucleoproteins - genetics Ribonucleoproteins - isolation & purification Ribonucleoproteins - metabolism RNA, Bacterial - chemistry RNA, Bacterial - genetics RNA, Bacterial - isolation & purification RNA, Bacterial - metabolism RNA, Catalytic - chemistry RNA, Catalytic - genetics RNA, Catalytic - isolation & purification RNA, Catalytic - metabolism Space life sciences
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Beschreibung
Zusammenfassung:	In vitro selection techniques are poised to allow a rapid expansion of the study of catalysis by RNA enzymes (ribozymes). This truly molecular version of genetics has already been applied to the study of the structures of known ribozymes and to the tailoring of their catalytic activity to meet specific requirements of substrate specificity or reaction conditions. During the past year, in vitro selection has been successfully used to isolate novel RNA catalysts from random sequence pools.
ISSN:	0959-440X 1879-033X
DOI:	10.1016/S0959-440X(94)90227-5