Pharmacokinetics of albendazole in man

The pharmacokinetics of albendazole were investigated in healthy volunteers and in patients receiving albendazole for treatment of hydatid disease. Unchanged albendazole was below detectable limits in plasma, urine, bile and cyst fluid. The major metabolite present in all fluids was the sulfoxide. M...

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Veröffentlicht in:	European journal of clinical pharmacology 1986-01, Vol.30 (6), p.705-708
Hauptverfasser:	MARRINER, S. E, MORRIS, D. L, DICKSON, B, BOGAN, J. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Absorption Adipose Tissue - metabolism Adult Albendazole Anthelmintics - blood Anthelmintics - metabolism Anthelmintics - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Benzimidazoles - blood Benzimidazoles - metabolism Benzimidazoles - therapeutic use Biological and medical sciences Echinococcosis - drug therapy Echinococcosis - metabolism Female Humans Kinetics Male Medical sciences Pharmacology. Drug treatments
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Zusammenfassung:	The pharmacokinetics of albendazole were investigated in healthy volunteers and in patients receiving albendazole for treatment of hydatid disease. Unchanged albendazole was below detectable limits in plasma, urine, bile and cyst fluid. The major metabolite present in all fluids was the sulfoxide. Maximum concentrations of albendazole sulfoxide in plasma were very variable, probably due to variable absorption of albendazole.
ISSN:	0031-6970 1432-1041
DOI:	10.1007/BF00608219