Regulation of cyclic AMP-dependent Cl- channel in heart

(1) alpha 1-Adrenoceptor stimulation inhibited the beta-adrenergic activation of Cl- current in guinea-pig ventricular cells. This alpha 1- and beta-adrenergic interaction appeared to be upstream in the cascade of adenylate cyclase activation. (2) Single Cl(-)-channel currents were recorded in cell-...

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Veröffentlicht in:	Japanese journal of physiology 1994, Vol.44 Suppl 2, p.S173-S176
Hauptverfasser:	Ehara, T, Iyadomi, I, Hirahara, K
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-Agonists Adrenergic beta-Antagonists Animals Chloride Channels - physiology Cyclic AMP - pharmacology Egtazic Acid - pharmacology Guinea Pigs Heart - physiology
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Zusammenfassung:	(1) alpha 1-Adrenoceptor stimulation inhibited the beta-adrenergic activation of Cl- current in guinea-pig ventricular cells. This alpha 1- and beta-adrenergic interaction appeared to be upstream in the cascade of adenylate cyclase activation. (2) Single Cl(-)-channel currents were recorded in cell-attached and excised outside-out patch membranes. Experiments were performed to investigate the dependence of channel behavior on the agonist concentrations.
ISSN:	0021-521X