New modified substrates for discriminating between human DNA polymerases α and ϵ
Two 2′-deoxynucleoside 5′-α-methylenephosphonyl-β,γ-diphosphates were synthesized. They were incorporated into the DNA chain by DNA polymerase α from human placenta. Meanwhile, they were not recognized by DNA polymerases ϵ and β of the same origin as well as by reverse transcriptases from human immu...
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| Veröffentlicht in: | FEBS letters 1995-01, Vol.357 (1), p.23-26 |
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| container_title | FEBS letters |
| container_volume | 357 |
| creator | Jasko, Maxim V. Semizarov, Dmitry G. Victorova, Lyubov S. Mozzherin, Dmitry Ju Krayevsky, Alexander A. Kukhanova, Marina K. |
| description | Two 2′-deoxynucleoside 5′-α-methylenephosphonyl-β,γ-diphosphates were synthesized. They were incorporated into the DNA chain by DNA polymerase α from human placenta. Meanwhile, they were not recognized by DNA polymerases ϵ and β of the same origin as well as by reverse transcriptases from human immunodeficiency virus and avian myeloblastosis virus. |
| doi_str_mv | 10.1016/0014-5793(94)01319-V |
| format | Article |
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They were incorporated into the DNA chain by DNA polymerase α from human placenta. Meanwhile, they were not recognized by DNA polymerases ϵ and β of the same origin as well as by reverse transcriptases from human immunodeficiency virus and avian myeloblastosis virus.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/0014-5793(94)01319-V</identifier><identifier>PMID: 7528146</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>2′,3′-dideoxynucleoside 5′-triphosphate ; 2′-deoxynucleoside 5′-monophosphate ; 2′-deoxynucleoside 5′-triphosphate ; AIDS/HIV ; AMV ; avian myeloblastosis virus ; Avian Myeloblastosis Virus - enzymology ; Base Sequence ; d2NTP ; DNA - metabolism ; DNA polymerase ; DNA polymerase I Klenow fragment from E. coli ; DNA Polymerase II - metabolism ; DNA-Directed DNA Polymerase - metabolism ; dNMP ; dNTP ; HIV ; HIV - enzymology ; human immunodeficiency virus ; Humans ; KFr ; Modified nucleoside 5′-triphosphate ; Molecular Sequence Data ; Nucleotides - metabolism ; Reverse transcriptase ; RNA-Directed DNA Polymerase - metabolism ; Substrate Specificity ; TdT ; Terminal deoxynucleotidyl transferase</subject><ispartof>FEBS letters, 1995-01, Vol.357 (1), p.23-26</ispartof><rights>1995</rights><rights>FEBS Letters 357 (1995) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366V-4954fab464a55424554782ff4b5e9a0a521109d50eddd79a139f7530f6b109a63</citedby><cites>FETCH-LOGICAL-c366V-4954fab464a55424554782ff4b5e9a0a521109d50eddd79a139f7530f6b109a63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/001457939401319V$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7528146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jasko, Maxim V.</creatorcontrib><creatorcontrib>Semizarov, Dmitry G.</creatorcontrib><creatorcontrib>Victorova, Lyubov S.</creatorcontrib><creatorcontrib>Mozzherin, Dmitry Ju</creatorcontrib><creatorcontrib>Krayevsky, Alexander A.</creatorcontrib><creatorcontrib>Kukhanova, Marina K.</creatorcontrib><title>New modified substrates for discriminating between human DNA polymerases α and ϵ</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Two 2′-deoxynucleoside 5′-α-methylenephosphonyl-β,γ-diphosphates were synthesized. They were incorporated into the DNA chain by DNA polymerase α from human placenta. Meanwhile, they were not recognized by DNA polymerases ϵ and β of the same origin as well as by reverse transcriptases from human immunodeficiency virus and avian myeloblastosis virus.</description><subject>2′,3′-dideoxynucleoside 5′-triphosphate</subject><subject>2′-deoxynucleoside 5′-monophosphate</subject><subject>2′-deoxynucleoside 5′-triphosphate</subject><subject>AIDS/HIV</subject><subject>AMV</subject><subject>avian myeloblastosis virus</subject><subject>Avian Myeloblastosis Virus - enzymology</subject><subject>Base Sequence</subject><subject>d2NTP</subject><subject>DNA - metabolism</subject><subject>DNA polymerase</subject><subject>DNA polymerase I Klenow fragment from E. coli</subject><subject>DNA Polymerase II - metabolism</subject><subject>DNA-Directed DNA Polymerase - metabolism</subject><subject>dNMP</subject><subject>dNTP</subject><subject>HIV</subject><subject>HIV - enzymology</subject><subject>human immunodeficiency virus</subject><subject>Humans</subject><subject>KFr</subject><subject>Modified nucleoside 5′-triphosphate</subject><subject>Molecular Sequence Data</subject><subject>Nucleotides - metabolism</subject><subject>Reverse transcriptase</subject><subject>RNA-Directed DNA Polymerase - metabolism</subject><subject>Substrate Specificity</subject><subject>TdT</subject><subject>Terminal deoxynucleotidyl transferase</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1O3DAUha0KBFPoGxTJK9QuQu3EP_EGiVIGkBCVUDtby4mvi1F-BjvpaB6ri75G-0p1mBFL6MaW7zn33OsPofeUnFBCxSdCKMu4VMUHxT4SWlCVLd6gGS1lkRVMlDto9mzZR29jfCDpXVK1h_Ykz0vKxAzd3cIKt731zoPFcaziEMwAEbs-YOtjHXzrOzP47geuYFgBdPh-bE2Hv9ye4WXfrFsIJqaGP7-w6Sz--_sQ7TrTRHi3vQ_Q9_nFt_Or7Obr5fX52U1WF0IsMqY4c6ZighnOWc7SIcvcOVZxUIYYnlNKlOUErLVSGVooJ3lBnKhS3YjiAB1vcpehfxwhDrpN-0LTmA76MWopSckTlleNVBJOREmSkW2MdehjDOD0Mn3fhLWmRE_M9QRUT0C1YvqJuV6ktqNt_li1YJ-btpCTPt_oK9_A-r8y9fzicz4JU12xp-o06HQTBAnrTw9Bx9pDV4P1AepB296_vOk_zpmkZA</recordid><startdate>19950102</startdate><enddate>19950102</enddate><creator>Jasko, Maxim V.</creator><creator>Semizarov, Dmitry G.</creator><creator>Victorova, Lyubov S.</creator><creator>Mozzherin, Dmitry Ju</creator><creator>Krayevsky, Alexander A.</creator><creator>Kukhanova, Marina K.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>19950102</creationdate><title>New modified substrates for discriminating between human DNA polymerases α and ϵ</title><author>Jasko, Maxim V. ; Semizarov, Dmitry G. ; Victorova, Lyubov S. ; Mozzherin, Dmitry Ju ; Krayevsky, Alexander A. ; Kukhanova, Marina K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c366V-4954fab464a55424554782ff4b5e9a0a521109d50eddd79a139f7530f6b109a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>2′,3′-dideoxynucleoside 5′-triphosphate</topic><topic>2′-deoxynucleoside 5′-monophosphate</topic><topic>2′-deoxynucleoside 5′-triphosphate</topic><topic>AIDS/HIV</topic><topic>AMV</topic><topic>avian myeloblastosis virus</topic><topic>Avian Myeloblastosis Virus - enzymology</topic><topic>Base Sequence</topic><topic>d2NTP</topic><topic>DNA - metabolism</topic><topic>DNA polymerase</topic><topic>DNA polymerase I Klenow fragment from E. coli</topic><topic>DNA Polymerase II - metabolism</topic><topic>DNA-Directed DNA Polymerase - metabolism</topic><topic>dNMP</topic><topic>dNTP</topic><topic>HIV</topic><topic>HIV - enzymology</topic><topic>human immunodeficiency virus</topic><topic>Humans</topic><topic>KFr</topic><topic>Modified nucleoside 5′-triphosphate</topic><topic>Molecular Sequence Data</topic><topic>Nucleotides - metabolism</topic><topic>Reverse transcriptase</topic><topic>RNA-Directed DNA Polymerase - metabolism</topic><topic>Substrate Specificity</topic><topic>TdT</topic><topic>Terminal deoxynucleotidyl transferase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jasko, Maxim V.</creatorcontrib><creatorcontrib>Semizarov, Dmitry G.</creatorcontrib><creatorcontrib>Victorova, Lyubov S.</creatorcontrib><creatorcontrib>Mozzherin, Dmitry Ju</creatorcontrib><creatorcontrib>Krayevsky, Alexander A.</creatorcontrib><creatorcontrib>Kukhanova, Marina K.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jasko, Maxim V.</au><au>Semizarov, Dmitry G.</au><au>Victorova, Lyubov S.</au><au>Mozzherin, Dmitry Ju</au><au>Krayevsky, Alexander A.</au><au>Kukhanova, Marina K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>New modified substrates for discriminating between human DNA polymerases α and ϵ</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>1995-01-02</date><risdate>1995</risdate><volume>357</volume><issue>1</issue><spage>23</spage><epage>26</epage><pages>23-26</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Two 2′-deoxynucleoside 5′-α-methylenephosphonyl-β,γ-diphosphates were synthesized. They were incorporated into the DNA chain by DNA polymerase α from human placenta. Meanwhile, they were not recognized by DNA polymerases ϵ and β of the same origin as well as by reverse transcriptases from human immunodeficiency virus and avian myeloblastosis virus.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>7528146</pmid><doi>10.1016/0014-5793(94)01319-V</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-5793 |
| ispartof | FEBS letters, 1995-01, Vol.357 (1), p.23-26 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77085131 |
| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 2′,3′-dideoxynucleoside 5′-triphosphate 2′-deoxynucleoside 5′-monophosphate 2′-deoxynucleoside 5′-triphosphate AIDS/HIV AMV avian myeloblastosis virus Avian Myeloblastosis Virus - enzymology Base Sequence d2NTP DNA - metabolism DNA polymerase DNA polymerase I Klenow fragment from E. coli DNA Polymerase II - metabolism DNA-Directed DNA Polymerase - metabolism dNMP dNTP HIV HIV - enzymology human immunodeficiency virus Humans KFr Modified nucleoside 5′-triphosphate Molecular Sequence Data Nucleotides - metabolism Reverse transcriptase RNA-Directed DNA Polymerase - metabolism Substrate Specificity TdT Terminal deoxynucleotidyl transferase |
| title | New modified substrates for discriminating between human DNA polymerases α and ϵ |
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