Genomic Analysis of the Human B-Lymphotropic Virus (HBLV)

The human B-lymphotropic virus (HBLV) has a double-stranded DNA genome of greater than 110 kilobase pairs, which is consistent with its morphological classification as a herpesvirus. A 9000--base pair cloned probe of HBLV detected specific sequences in DNA and RNA of infected cells but did not hybri...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1986-10, Vol.234 (4776), p.601-603
Hauptverfasser:	Josephs, Steven F., Salahuddin, S. Zaki, Ablashi, Dharam V., Schachter, Francois, Wong-Staal, Flossie, Gallo, Robert C.
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS (Disease) AIDS research Biochemistry Biological and medical sciences Blood cells Cytomegalovirus - genetics DNA DNA probes DNA, Viral - genetics Epstein Barr virus infections Fundamental and applied biological sciences. Psychology Genetics Genomics Herpes viruses Herpesviridae Herpesviridae - genetics herpesvirus Herpesvirus 2, Saimiriine - genetics Herpesvirus 3, Human - genetics Herpesvirus 4, Human - genetics Herpesviruses Human herpesvirus Human herpesvirus 1 Human herpesvirus 6 Humans Innovations Medical research Microbiology Nucleic Acid Hybridization Parasites Simplexvirus - genetics Systematics Viral research Virology Virus research Viruses
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Zusammenfassung:	The human B-lymphotropic virus (HBLV) has a double-stranded DNA genome of greater than 110 kilobase pairs, which is consistent with its morphological classification as a herpesvirus. A 9000--base pair cloned probe of HBLV detected specific sequences in DNA and RNA of infected cells but did not hybridize to the genomic DNA of other human herpesviruses including the Epstein-Barr virus, human cytomegalovirus, herpes simplex type I, and varicella-zoster virus. Conversely, while probes obtained from each of the known human herpesvirus readily detected the homologous viral DNA, they did not hybridize to genomic HBLV DNA. This evidence, in addition to serological and morphological distinctions and the biological effects of this virus demonstrate that HBLV is a novel human herpesvirus.
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.3020691