Searching for microsatellite mutations in coding regions in lung, breast, ovarian and colorectal cancers

RepX represents a new informatics approach to probe the UniGene database for potentially polymorphic repeat sequences in the open reading frame (ORF) of genes, 56% of which were found to be actually polymorphic. We now have performed mutational analysis of 17 such sites in genes not found to be poly...

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Veröffentlicht in:	Oncogene 2001-02, Vol.20 (8), p.1005-1009
Hauptverfasser:	FORGACS, Eva, WREN, Jonathan D, MINNA, John D, KAMIBAYASHI, Craig, KONDO, Masashi, XU, Xie L, MARKOWITZ, Sanford, TOMLINSON, Gail E, MULLER, Carolyn Y, GAZDAR, Adi F, GARNER, Harold R
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Pair Mismatch Biological and medical sciences Breast Breast cancer Breast carcinoma Breast Neoplasms - genetics Cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - genetics Databases, Factual Female Fundamental and applied biological sciences. Psychology Genetic testing Genetics of eukaryotes. Biological and molecular evolution Human Humans Informatics Lung cancer Lung carcinoma Lung Neoplasms - genetics Microsatellite instability Microsatellite Repeats - genetics Mismatch repair Mutation Oncology Open reading frames Ovarian carcinoma Ovarian Neoplasms - genetics Ovaries Polymorphism, Single-Stranded Conformational Population genetics, reproduction patterns Reading Software Sterol regulatory element-binding protein Tumor cell lines Tumors Yeast
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Beschreibung
Zusammenfassung:	RepX represents a new informatics approach to probe the UniGene database for potentially polymorphic repeat sequences in the open reading frame (ORF) of genes, 56% of which were found to be actually polymorphic. We now have performed mutational analysis of 17 such sites in genes not found to be polymorphic (
ISSN:	0950-9232 1476-5594
DOI:	10.1038/sj.onc.1204211