Malignant fibrous histiocytoma (MFH) cells and macrophages/histiocytes have a common antigen recognized by a monoclonal antibody risen against a rat MFH-derived cloned cell line

A monoclonal antibody (B9) was generated by using a rat malignant fibrous histiocytoma (MFH)-derived cloned cell line (MT-8) as the immunogen. Immunohistochemically, B9 reacted specifically with a cytoplasmic antigen of MT-8 cells. Furthermore, B9 immunolabeled another MFH-derived cloned cells (MT-9...

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Veröffentlicht in:Journal of Veterinary Medical Science 2001, Vol.63(3), pp.333-335
Hauptverfasser: Kumagai, D. (Osaka Prefectural Univ., Sakai (Japan). Coll. of Agriculture), Yamate, J, Tajima, T, Kuwamura, M, Kotani, T, Sakuma, S
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Sprache:eng
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Zusammenfassung:A monoclonal antibody (B9) was generated by using a rat malignant fibrous histiocytoma (MFH)-derived cloned cell line (MT-8) as the immunogen. Immunohistochemically, B9 reacted specifically with a cytoplasmic antigen of MT-8 cells. Furthermore, B9 immunolabeled another MFH-derived cloned cells (MT-9) and histiocytic sarcoma cells, as well as macrophages/histiocytes in normal and diseased tissues of rats. These findings suggest the presence of a common antigen recognized by B9 between MFH cells and macrophages/histiocytes. This suggests that MFH cells may express histiocytic nature.
ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.63.333